Environmental Health and Toxicology Lab, Department of Environmental Sciences, School of Life Sciences, 364343Bharathiar University, Coimbatore, India.
Cardiovascular Biology Lab, Department of Biochemistry and Biotechnology, Faculty of Science, 364050Annamalai University, Chidambaram, India.
Hum Exp Toxicol. 2021 Dec;40(12_suppl):S654-S665. doi: 10.1177/09603271211053285. Epub 2021 Nov 19.
Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and "safe" dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period. The results illustrate that a 'safe' dose of BPA does not influence the systolic blood pressure (SBP) and levels of circulatory biomarkers of tissue damage. On the other hand, BPA exposure significantly ( < 0.05) elevates the thiobarbituric acid reactive substances (TBARS) content in plasma and tissues (heart, aorta, liver and kidney) in hypertensive rats when compared with respective control (BPA alone exposed) rats. Similarly, a significant modulation of ROS generation in RBC, plasma nitric oxide (NO) level and angiotensin-converting enzyme (ACE) activity was observed only under hypertensive milieu. In conclusion, the observed adverse effects during 'safe' dose of BPA exposure are specific to the hypertensive condition. Therefore, a precise investigation to explore the effects of BPA exposure in vulnerable hypertensive populations is highly suggested.
由于高血压（心血管疾病的主要危险因素之一）在人群中的普遍存在，因此有必要探讨在高血压情况下，每日可耐受和“安全”剂量的双酚 A（BPA）的不良影响。本研究通过口服给予 Nω-硝基-l-精氨酸甲酯（L-NAME，40mg/kg b.w/day）诱导的高血压 Wistar 大鼠 50μg/kg b.w/day 的 BPA，同时设置适当的对照组，进行了为期 30 天的实验。结果表明，“安全”剂量的 BPA 不会影响收缩压（SBP）和循环组织损伤生物标志物的水平。另一方面，与相应的对照组（仅暴露于 BPA 的大鼠）相比，BPA 暴露会显著（<0.05）增加高血压大鼠血浆和组织（心脏、主动脉、肝脏和肾脏）中的丙二醛（TBARS）含量。同样，仅在高血压环境下才观察到 RBC 中 ROS 生成、血浆一氧化氮（NO）水平和血管紧张素转换酶（ACE）活性的显著调节。总之，在“安全”剂量的 BPA 暴露期间观察到的不良影响是特定于高血压状态的。因此，强烈建议对易患高血压的人群进行 BPA 暴露影响的精确研究。
