Wellcome Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, Oxford, UK.
University of Coimbra, Multidisciplinary Institute of Ageing, Coimbra, Portugal.
J Cell Biol. 2021 Dec 6;220(12). doi: 10.1083/jcb.202111056. Epub 2021 Nov 19.
The regulation of activity-dependent bulk endocytosis, the dominant mode of membrane retrieval in response to intense neuronal activity, is poorly understood. In this JCB issue, Peng et al. (2021. J. Cell. Biol.https://doi.org/10.1083/jcb.202011028) propose a novel molecular mechanism for the coordination of activity-dependent bulk endocytosis that builds on Minibrain kinase and its presynaptic substrate synaptojanin-1.
活性依赖性胞吞作用的调节，是对强烈神经元活动做出反应的主要膜回收方式，但目前对此知之甚少。在本期《细胞生物学杂志》中，Peng 等人（2021. J. Cell. Biol. https://doi.org/10.1083/jcb.202011028）提出了一个新的分子机制，用于协调活性依赖性胞吞作用，该机制建立在 Minibrain 激酶及其突触前底物 synaptojanin-1 的基础上。
