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比较各种用于人类 T 淋巴细胞白血病病毒-1(HTLV-1)检测的生物传感器方法。

Comparison between various biosensor methods for human T-lymphotropic virus-1 (HTLV-1) detection.

机构信息

Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Mol Biol Rep. 2022 Feb;49(2):1513-1517. doi: 10.1007/s11033-021-06959-w. Epub 2021 Nov 19.

Abstract

Due to the drawback of traditional and current diagnostic methods including serological and molecular assays, the development of the rapid and free-PCR techniques can be an alternative technique for the human T-cell lymphotropic virus (HTLV-1) DNA detection sequences. On the other hand, early detection of HTLV-1 prevents two dangerous diseases including Adult T-cell leukemia/lymphoma and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis. The biosensor-based methods are sensitive techniques that can provide new opportunities to detect infectious diseases, particularly in the early stage. This study provides a comparative view among recently designed biosensors for the detection of HTLV-1.

摘要

由于传统和当前的诊断方法(包括血清学和分子检测)存在缺陷,因此快速且无需 PCR 的技术的发展可以作为人类 T 细胞嗜淋巴细胞病毒(HTLV-1)DNA 检测序列的替代技术。另一方面,及早检测 HTLV-1 可预防两种危险疾病,即成人 T 细胞白血病/淋巴瘤和 HTLV-1 相关脊髓病/热带痉挛性截瘫。基于生物传感器的方法是灵敏的技术,可以为传染病的检测,特别是早期检测提供新的机会。本研究比较了最近设计的用于检测 HTLV-1 的生物传感器。

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