Orion Institute for Translational Medicine, United States.
Orion Institute for Translational Medicine, United States; Emergent Biotechnologies LLC, United States.
Pregnancy Hypertens. 2022 Mar;27:1-5. doi: 10.1016/j.preghy.2021.10.012. Epub 2021 Nov 5.
This study evaluated urinary angiotensinogen in preeclampsia.
Normal pregnant (n = 57) and preeclamptic patients (n = 31); Normal pregnant (n = 10) and preeclamptic rats (n = 10) were studied. Urinary angiotensinogen and plasma angiotensin II were assayed by enzyme-linked immunosorbent assay (ELISA).
Urinary angiotensinogen in preeclampsia patients (2.0 ± 1.1 ng/mg creatinine) was suppressed (*p < 0.05) compared to normal pregnant (2.7 ± 1.5 ng/mg creatinine). Plasma angiotensin II in preeclampsia patients (preeclampsia: 36.2 ± 7; normal pregnant: 48.1 ± 5 fmol/mL) was lower. The similar result was observed in preeclampsia rat model.
The reduced urinary excretion of angiotensinogen was both in human preeclampsia patients and rat model of preeclampsia.
本研究评估了子痫前期患者的尿血管紧张素原。
正常妊娠（n=57）和子痫前期患者（n=31）；正常妊娠（n=10）和子痫前期大鼠（n=10）。采用酶联免疫吸附试验（ELISA）测定尿血管紧张素原和血浆血管紧张素 II。
子痫前期患者的尿血管紧张素原（2.0±1.1ng/mg 肌酐）低于正常妊娠患者（2.7±1.5ng/mg 肌酐）（*p<0.05）。子痫前期患者的血浆血管紧张素 II（子痫前期：36.2±7；正常妊娠：48.1±5fmol/mL）也较低。子痫前期大鼠模型也观察到了类似的结果。
在人类子痫前期患者和子痫前期大鼠模型中，尿血管紧张素原的排泄减少。
