先兆子痫患者尿血管紧张素原排泄减少。
Reduced urinary angiotensinogen excretion in preeclampsia.
机构信息
Orion Institute for Translational Medicine, United States.
Orion Institute for Translational Medicine, United States; Emergent Biotechnologies LLC, United States.
出版信息
Pregnancy Hypertens. 2022 Mar;27:1-5. doi: 10.1016/j.preghy.2021.10.012. Epub 2021 Nov 5.
OBJECTIVE
This study evaluated urinary angiotensinogen in preeclampsia.
METHODS
Normal pregnant (n = 57) and preeclamptic patients (n = 31); Normal pregnant (n = 10) and preeclamptic rats (n = 10) were studied. Urinary angiotensinogen and plasma angiotensin II were assayed by enzyme-linked immunosorbent assay (ELISA).
RESULTS
Urinary angiotensinogen in preeclampsia patients (2.0 ± 1.1 ng/mg creatinine) was suppressed (*p < 0.05) compared to normal pregnant (2.7 ± 1.5 ng/mg creatinine). Plasma angiotensin II in preeclampsia patients (preeclampsia: 36.2 ± 7; normal pregnant: 48.1 ± 5 fmol/mL) was lower. The similar result was observed in preeclampsia rat model.
CONCLUSIONS
The reduced urinary excretion of angiotensinogen was both in human preeclampsia patients and rat model of preeclampsia.
目的
本研究评估了子痫前期患者的尿血管紧张素原。
方法
正常妊娠（n=57）和子痫前期患者（n=31）；正常妊娠（n=10）和子痫前期大鼠（n=10）。采用酶联免疫吸附试验（ELISA）测定尿血管紧张素原和血浆血管紧张素 II。
结果
子痫前期患者的尿血管紧张素原（2.0±1.1ng/mg 肌酐）低于正常妊娠患者（2.7±1.5ng/mg 肌酐）（*p<0.05）。子痫前期患者的血浆血管紧张素 II（子痫前期：36.2±7；正常妊娠：48.1±5fmol/mL）也较低。子痫前期大鼠模型也观察到了类似的结果。
结论
在人类子痫前期患者和子痫前期大鼠模型中，尿血管紧张素原的排泄减少。
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