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心脏手术后虚弱状态的变化。一项前瞻性队列研究。

Changes in frailty status after cardiac surgery. A prospective cohort study.

机构信息

Department of Cardiac Surgery, Ramon y Cajal University Hospital, Madrid, Spain.

Department of Cardiac Surgery, Ramon y Cajal University Hospital, Madrid, Spain.

出版信息

Arch Gerontol Geriatr. 2022 Jan-Feb;98:104568. doi: 10.1016/j.archger.2021.104568. Epub 2021 Nov 9.

Abstract

BACKGROUND

The concept of frailty has become increasingly familiar in cardiac surgery. Since one of the characteristics of frailty is its reversible nature, efforts are being made to preoperatively decrease the level of frailty. However, the effect that the surgery itself may have in the postoperative frailty status remains still unknown.

METHODS

A prospective cohort of 137 patients aged 70 or more undergoing major cardiac surgery were recruited at three hospitals in Spain. Frailty status was assessed preoperatively and six months after surgery using the Fried scale and the Clinical Frailty Scale (CFS). We analyzed the changes in these frailty scores and the transitions between frailty status after surgery.

RESULTS

Mean age of participants was 78.3 years. 47.7% were female. Prevalence of frailty was 27.5% with the Fried Scale and 11% with the CFS. Up to 50% of frail patients improved their frailty status after surgery. The distribution of frailty among the study groups at baseline and six months after surgery changed significantly, decreasing the overall burden of frailty after surgery: 27.5% vs 17.4% of frail patients with the Fried Scale and 50.5% vs 29.4% of vulnerable or frail patients with the CFS (p<0.01).

CONCLUSIONS

Frailty is a dynamic condition that can be significantly reduced after cardiac surgery, suggesting that cardiac pathology is an important contributor to the preoperative patient's frailty status.

摘要

背景

衰弱的概念在心脏外科中越来越被熟悉。由于衰弱的一个特征是其可逆性,因此正在努力在术前降低衰弱的程度。然而,手术本身可能对术后衰弱状态的影响仍然未知。

方法

在西班牙的三家医院,对 137 名 70 岁或以上的接受大型心脏手术的患者进行了前瞻性队列研究。使用 Fried 量表和临床虚弱量表(CFS)在术前和术后 6 个月评估虚弱状况。我们分析了这些虚弱评分的变化以及手术后虚弱状态之间的转变。

结果

参与者的平均年龄为 78.3 岁。47.7%为女性。衰弱的患病率为 27.5%,用 Fried 量表,11%用 CFS。多达 50%的虚弱患者在手术后改善了虚弱状态。在基线和术后 6 个月,研究组之间的虚弱分布发生了显著变化,术后整体虚弱负担降低:用 Fried 量表,27.5%的虚弱患者下降到 17.4%,用 CFS,50.5%的脆弱或虚弱患者下降到 29.4%(p<0.01)。

结论

衰弱是一种动态的状态,可以在心脏手术后显著减轻,这表明心脏病理学是术前患者衰弱状态的一个重要贡献因素。

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