Leppert M, Dobbs M, Scambler P, O'Connell P, Nakamura Y, Stauffer D, Woodward S, Burt R, Hughes J, Gardner E
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah Medical Center, Salt Lake City 84132.
Science. 1987 Dec 4;238(4832):1411-3. doi: 10.1126/science.3479843.
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.
腺瘤性息肉病的遗传性基因缺陷已定位到5号染色体长臂上的一个小区域。使用16个DNA标记位点构建了该染色体的连锁图谱。当用一些标记对分离腺瘤性息肉病基因的五个家系进行特征分析时，发现一个标记与疾病基因之间存在显著连锁。连锁分析确定了缺陷基因在5号染色体初级遗传图谱中的位置。
