Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, 5200 Centre Avenue, Suite 409, Pittsburgh, PA 15232, USA.
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, 5200 Centre Avenue, Suite 409, Pittsburgh, PA 15232, USA.
Gastrointest Endosc Clin N Am. 2022 Jan;32(1):13-25. doi: 10.1016/j.giec.2021.08.008.
Individuals with a genetic susceptibility to pancreatic ductal adenocarcinoma (PDAC) may benefit from surveillance to increase the likelihood of early detection. Currently, candidates for surveillance are identified based on genetic test results and family history of PDAC, and surveillance is accomplished through imaging of the pancreas (endoscopic ultrasound or MRI). Novel methods that incorporate personalized risk, biomarkers, and radiomics are being investigated in an attempt to improve identification of at-risk individuals and to increase detection of precursor and early-stage lesions.
具有胰腺导管腺癌 (PDAC) 遗传易感性的个体可能受益于监测，以提高早期发现的可能性。目前，监测的候选者是根据遗传检测结果和 PDAC 的家族史确定的，监测是通过胰腺成像（内镜超声或 MRI）来完成的。目前正在研究新的方法，将个性化风险、生物标志物和放射组学结合起来，试图提高高危个体的识别能力，并提高对前体和早期病变的检测能力。
