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利用基因组信息进行北欧红牛的交配分配。

Mating allocations in Nordic Red Dairy Cattle using genomic information.

机构信息

VikingGenetics, VikingGenetics Sweden AB, 53294 Skara, Sweden; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, 75007 Uppsala, Sweden.

VikingGenetics, VikingGenetics Sweden AB, 53294 Skara, Sweden.

出版信息

J Dairy Sci. 2022 Feb;105(2):1281-1297. doi: 10.3168/jds.2021-20849. Epub 2021 Nov 17.

Abstract

In this study, we compared mating allocations in Nordic Red Dairy Cattle using genomic information. We used linear programming to optimize different economic scores within each herd, considering genetic level, semen cost, the economic impact of recessive genetic defects, and genetic relationships. We selected 9,841 genotyped females born in Denmark, Finland, or Sweden in 2019 for mating allocations. We used 2 different pedigree relationship coefficients, the first tracing the pedigree 3 generations back from the parents of the potential mating and the second based on all available pedigree information. We used 3 different genomic relationship coefficients, 1 SNP-by-SNP genomic relationship and 2 based on shared genomic segments. We found high correlations (≥0.83) between the pedigree and genomic relationship measures. The mating results showed that it was possible to reduce the different genetic relationships between parents with minimal effect on genetic level. Including the cost of known recessive genetic defects eliminated expression of genetic defects. It was possible to reduce genomic relationships between parents with pedigree measures, but it was best done with genomic measures. Linear programming maximized the economic score for all herds studied within seconds, which means that it is suitable for implementation in mating software to be used by advisors and farmers.

摘要

在这项研究中,我们利用基因组信息比较了北欧红牛的配种分配。我们使用线性规划在每个牛群中优化不同的经济评分,考虑遗传水平、精液成本、隐性遗传缺陷的经济影响以及遗传关系。我们选择了 2019 年在丹麦、芬兰或瑞典出生的 9841 头经过基因分型的雌性进行配种分配。我们使用了 2 种不同的系谱关系系数,第一种从潜在配种父母的 3 代前追溯系谱,第二种基于所有可用的系谱信息。我们使用了 3 种不同的基因组关系系数,1 种 SNP-by-SNP 基因组关系和 2 种基于共享基因组片段的关系。我们发现系谱和基因组关系度量之间存在高度相关性(≥0.83)。配种结果表明,可以在最小化遗传水平影响的情况下,减少父母之间的不同遗传关系。包括已知隐性遗传缺陷的成本可以消除遗传缺陷的表达。可以使用系谱措施降低父母之间的基因组关系,但最好使用基因组措施。线性规划在几秒钟内为所有研究的牛群最大化了经济评分,这意味着它适合在配种软件中实施,供顾问和农民使用。

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