Saravia M E, Currie W R, Campbell R L
Anesth Prog. 1987 May-Jun;34(3):92-6.
Twenty pediatric patients were sedated with a meperidine, Promethazine and chlorpromazine drug combination prior to dental rehabilitation. Heart rate, blood pressure, and oxygen saturation were recorded throughout the procedures, as well as level of patient cooperation. There were no statistically significant changes in either heart rate or blood pressure. Forty-seven percent of subjects treated experienced a decline in oxygen hemoglobin saturation. Fifty percent of the patients were well sedated and cooperative, with another forty-five precent exhibiting moderate sedation but an increased incidence of behavioral management difficulties. All procedures were completed on 95% of patients. One case (5%) was aborted because of uncontrollable patient behavior following initiation of dental procedures.
20名儿科患者在进行牙齿修复前使用了哌替啶、异丙嗪和氯丙嗪的药物组合进行镇静。在整个过程中记录心率、血压和血氧饱和度，以及患者的配合程度。心率和血压均无统计学上的显著变化。47%接受治疗的受试者血氧血红蛋白饱和度下降。50%的患者镇静良好且配合，另有45%表现为中度镇静，但行为管理困难的发生率增加。95%的患者完成了所有程序。1例（5%）因开始牙科治疗后患者行为无法控制而中止。
