Accurate College of Pharmacy, Knowledge Park III, Greater Noida, UP, India.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Kedah, Malaysia.
Pak J Pharm Sci. 2021 Jul;34(4):1397-1401.
The current research was aimed to isolate newer phyto-metabolites from rhizomes of Alpinia galanga plant. Study involved preparation of Alpinia galanga rhizome methanolic extract, followed by normal phase column chromatography assisted isolation of new phytometabolites (using different combinations of chloroform and methanol), and characterization (by UV, FTIR, 13C-NMR, 1H-NMR, COSY, DEPT and Mass spectrometry). The isolation and characterization experiment offered two phytometabolites: an ester (Ag-1) and tetrahydronapthalene type lactone (Ag-2). Present study concludes and reports the two phytometabolites, benzyl myristate (Ag-1) and 3-Methyl-6α, 8β-diol-7-carboxylic acid tetralin-11, 9β-olide (Ag-2) for the first time in Alpinia galanga rhizome. The study recommends that these phytometabolites Ag-1 and Ag-2 can be utilized as effective analytical biomarkers for identification, purity and quality control of this plant in future.
本研究旨在从高良姜根茎中分离出新的植物代谢物。研究包括制备高良姜根茎甲醇提取物,然后通过正相柱层析辅助分离新的植物代谢物(使用不同比例的氯仿和甲醇),并进行表征(通过 UV、FTIR、13C-NMR、1H-NMR、COSY、DEPT 和质谱)。分离和表征实验提供了两种植物代谢物:一种酯(Ag-1)和四氢萘内酯型内酯(Ag-2)。本研究首次在高良姜根茎中报告了两种植物代谢物:肉豆蔻酸苄酯(Ag-1)和 3-甲基-6α,8β-二醇-7-羧酸四氢萘-11,9β-内酯(Ag-2)。该研究建议,这些植物代谢物 Ag-1 和 Ag-2 可作为未来鉴定、纯度和质量控制该植物的有效分析生物标志物加以利用。