Karjalainen S, Söderling E, Pelliniemi L, Foidart J M
Institute of Dentistry, University of Turku, Finland.
Arch Oral Biol. 1986;31(12):801-6. doi: 10.1016/0003-9969(86)90131-7.
Reparative dentine formed as a response to caries was mostly type I collagen similar to that of normal dentine. The predentine related to reparative dentine reacted positively with antisera to types I and III collagen and to fibronectin. Normal odontoblasts and their processes reacted positively both with types I and III collagen antibodies. Fibronectin was related to odontoblasts and their processes pericellularly. Odontoblasts appeared not to lose totally their developmental ability to synthesize type III-like molecules after maturation. Pulp fibroblasts reacted positively both with types I and III antibodies as well as antifibronectin. The cell-free and cell-rich zones revealed a dense layer of fibres reacting positively with type III collagen and fibronectin antibodies. The width of these zones were reduced in relation to reparative dentine.
作为对龋齿的反应而形成的修复性牙本质主要是与正常牙本质相似的I型胶原蛋白。与修复性牙本质相关的前期牙本质与I型和III型胶原蛋白以及纤连蛋白的抗血清发生阳性反应。正常的成牙本质细胞及其突起与I型和III型胶原蛋白抗体均发生阳性反应。纤连蛋白在成牙本质细胞及其突起周围呈细胞周围分布。成牙本质细胞成熟后似乎并未完全丧失合成III型样分子的发育能力。牙髓成纤维细胞与I型和III型抗体以及抗纤连蛋白均发生阳性反应。无细胞区和富细胞区显示出一层致密的纤维，与III型胶原蛋白和纤连蛋白抗体发生阳性反应。相对于修复性牙本质，这些区域的宽度减小。
