Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi, 755-8505, Japan.
Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
Sci Rep. 2021 Nov 19;11(1):22615. doi: 10.1038/s41598-021-02004-9.
Postpartum depression is an important mental health issue not only for the mother but also for the child's development, other family members, and the society. An appropriate animal model is desired to elucidate the pathogenesis of postpartum depression. However, methods for stress loading during pregnancy have not been established. Behavioral experiments to investigate postpartum depression-like behaviors should be conducted without stress because behavioral tests affect rearing behaviors such as lactation. Therefore, we developed a new mouse model of postpartum depression using a psychological stress method. Mating partners were made to witness their partners experiencing social defeat stress and then listen to their cries. Emotional stress loading during pregnancy significantly increased postpartum depression-like behaviors. Postpartum depression also affected nurturing behaviors and caused disturbances in pup care. Furthermore, nesting behavior was impaired in the stressed group, suggesting that the observation of nesting behavior may be useful for assessing social dysfunction in postpartum depression. These results demonstrate the utility of this new mouse model of postpartum depression.
产后抑郁症不仅对母亲，而且对儿童的发展、其他家庭成员和社会都是一个重要的心理健康问题。需要一种合适的动物模型来阐明产后抑郁症的发病机制。然而，在怀孕期间进行应激加载的方法尚未建立。为了不影响哺乳等养育行为，应该进行没有应激的产后抑郁样行为的行为实验。因此，我们使用心理应激方法开发了一种新的产后抑郁症小鼠模型。让交配伴侣目睹他们的伴侣经历社会挫败应激，然后听他们的叫声。怀孕期间的情绪应激加载显著增加了产后抑郁样行为。产后抑郁症还影响了养育行为，并导致了幼仔护理的紊乱。此外，应激组的筑巢行为受损，这表明观察筑巢行为可能有助于评估产后抑郁症中的社交功能障碍。这些结果表明了这种新的产后抑郁症小鼠模型的实用性。
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