Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Warsaw, Poland.
Department of Urology, Military Institute of Medicine, Warsaw, Poland.
Pol Merkur Lekarski. 2021 Oct 22;49(293):329-333.
Data concerning the influence of sex hormones on body composition in women with chronic kidney disease (CKD) is limited.
The aim of our study was to define free testosterone levels and their association with body composition, biochemical markers of nutrition in females with CKD.
47 women were included into the study. 13 females treated with hemodialysis formed the hemodialysis group (HD), 24 females with CKD stage IV/V (eGFR < 30 ml/min/1,73 m2) formed the predialysis group (PreD), and 10 females without kidney disease formed the control group (C). Lean tissue mass (LTM) and fat mass (Fat) were measured using bioimpedance spectroscopy. Free testosterone levels were assessed using ELISA (IBL International). Statistical analysis was performed using Statistica v 13.1.
The median free testosterone (fT) levels were 0.7, 0.6, 0.85 pg/ml respectively for HD, PreD and C group. The median fT did not differ significantly between the groups (p=0.24). The mean LTM was 28.5 ±5.6, 27.3 ±4.9, 30.6 ±4.3 kg, mean Fat mass was 22.7 ±8.5, 31.3 ±9.8, 31.6 ±8.5 kg for the HD, PreD and C groups respectively. Positive correlations were observed between fT and LTM (r=0.306, p=0.035) in the whole study group. A negative correlation was observed between fT and age (r=-0.284) but was on the border of statistical significance (p=0.052).
In women with advanced CKD, median testosterone levels did not differ significantly from those observed in women without kidney failure. Free testosterone levels were associated with the amount of muscle mass in the whole study population.
本研究旨在定义游离睾酮水平及其与女性慢性肾脏病（CKD）患者身体成分、营养生化标志物的关系。
纳入 47 名女性进行研究。13 名接受血液透析的女性为血液透析组（HD），24 名 CKD Ⅳ/Ⅴ期（eGFR < 30 ml/min/1.73 m2）患者为预透析组（PreD），10 名无肾病女性为对照组（C）。使用生物电阻抗谱法测量瘦组织质量（LTM）和脂肪质量（Fat）。使用 ELISA（IBL International）评估游离睾酮水平。使用 Statistica v 13.1 进行统计分析。
HD、PreD 和 C 组的游离睾酮（fT）中位数分别为 0.7、0.6 和 0.85 pg/ml。组间 fT 中位数无显著差异（p=0.24）。LTM 的平均值分别为 28.5 ±5.6、27.3 ±4.9 和 30.6 ±4.3 kg，Fat 质量的平均值分别为 22.7 ±8.5、31.3 ±9.8 和 31.6 ±8.5 kg。整个研究组中，fT 与 LTM 呈正相关（r=0.306，p=0.035）。fT 与年龄呈负相关（r=-0.284），但接近统计学意义（p=0.052）。
在 CKD 晚期女性中，游离睾酮水平与无肾功能衰竭女性相比无显著差异。游离睾酮水平与整个研究人群的肌肉量有关。
