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Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.

作者信息

Bartram C R, Bross-Bach U, Schmidt H, Waller H D

机构信息

Department of Pediatrics II, University of Ulm, Federal Republic of Germany.

出版信息

Blut. 1987 Dec;55(6):505-11. doi: 10.1007/BF00320220.

DOI:10.1007/BF00320220
PMID:3480009
Abstract

We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot analysis identified a chimeric 8 kb bcr/abl RNA transcript in leukemic cells. These data suggest that 1. less bcr coding sequences than previously assumed may be essential for the putative transforming activity of the rearranged bcr/abl gene and 2. the bcr probes currently used for diagnostic purposes could miss Ph-positive CML cases.

摘要

相似文献

1
Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.
Blut. 1987 Dec;55(6):505-11. doi: 10.1007/BF00320220.
2
Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia.费城染色体阳性急性淋巴细胞白血病中BCR与ABL基因融合的异质性
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2795-9. doi: 10.1073/pnas.85.8.2795.
3
Structural organization of the bcr gene and its role in the Ph' translocation.bcr基因的结构组织及其在费城染色体易位中的作用。
Nature. 1985;315(6022):758-61. doi: 10.1038/315758a0.
4
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.费城染色体阳性急性淋巴细胞白血病中bcr和c-abl基因的独特融合
Cell. 1987 Oct 9;51(1):33-40. doi: 10.1016/0092-8674(87)90007-9.
5
The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5' of the breakpoint cluster region.
Cancer Genet Cytogenet. 1988 Jun;32(2):217-27. doi: 10.1016/0165-4608(88)90284-1.
6
Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region.
Blood. 1987 Nov;70(5):1659-64.
7
Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.费城染色体阳性慢性髓性白血病（CML）中9号和22号染色体的断点。CML急变期重排的c-abl癌基因的扩增。
J Clin Invest. 1986 Nov;78(5):1392-6. doi: 10.1172/JCI112726.
8
The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases.
Blood. 1988 Feb;71(2):349-55.
9
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.慢性粒细胞白血病和费城染色体患者中新型嵌合bcr/c-abl mRNA的证据。
N Engl J Med. 1985 Dec 5;313(23):1429-33. doi: 10.1056/NEJM198512053132301.
10
Rearrangement of the breakpoint cluster region and expression of P210 BCR-ABL in a "masked" Philadelphia chromosome-positive acute myeloid leukemia.
Blood. 1988 Nov;72(5):1829-32.

引用本文的文献

1
Chronic myeloid leukemia presenting ALL-type BCR/ABL transcript.呈现ALL型BCR/ABL转录本的慢性髓性白血病
Ann Hematol. 1994 Oct;69(4):189-93. doi: 10.1007/BF02215952.
2
Fine mapping of chromosome 22 breakpoints within the breakpoint cluster region (bcr) implies a role for bcr exon 3 in determining disease duration in chronic myeloid leukemia.22号染色体断点簇区域（bcr）内断点的精细定位表明bcr外显子3在决定慢性粒细胞白血病疾病持续时间中起作用。
Am J Hum Genet. 1989 Nov;45(5):729-38.
3
bcr rearrangement and C-abl gene expression in Ph1-positive hybrid acute leukemia with simultaneous proliferation of lymphoid and myeloid blasts.

本文引用的文献

1
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.在慢性粒细胞白血病中，一种细胞癌基因易位至费城染色体。
Nature. 1982 Dec 23;300(5894):765-7. doi: 10.1038/300765a0.
2
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
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3
Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells.
Ph1阳性混合性急性白血病中bcr重排及C-abl基因表达，伴有淋巴母细胞和髓母细胞同时增殖。
Blut. 1989 May;58(5):241-6. doi: 10.1007/BF00320912.
K-562及其他慢性粒细胞白血病细胞中c-abl癌基因转录的改变。
Science. 1984 Jul 6;225(4657):72-4. doi: 10.1126/science.6587568.
4
Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.c - ab1癌基因的易位与慢性粒细胞白血病中费城染色体的存在相关。
Nature. 1983;306(5940):277-80. doi: 10.1038/306277a0.
5
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.费城染色体断点聚集在22号染色体上一个有限的区域——bcr内。
Cell. 1984 Jan;36(1):93-9. doi: 10.1016/0092-8674(84)90077-1.
6
Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia.慢性粒细胞白血病中与易位断点相邻的c-ab1癌基因的定位。
Nature. 1983;306(5940):239-42. doi: 10.1038/306239a0.
7
An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.慢性粒细胞白血病中的一种8千碱基abl RNA转录本。
Proc Natl Acad Sci U S A. 1984 Sep;81(18):5648-52. doi: 10.1073/pnas.81.18.5648.
8
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.信件：通过喹吖因荧光和吉姆萨染色鉴定出慢性粒细胞白血病中一种新的一致染色体异常。
Nature. 1973 Jun 1;243(5405):290-3. doi: 10.1038/243290a0.
9
DNA content and DNA-based centromeric index of the 24 human chromosomes.24条人类染色体的DNA含量及基于DNA的着丝粒指数
Science. 1973 Mar 16;179(4078):1126-9. doi: 10.1126/science.179.4078.1126.
10
Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.体外检测c-abl酪氨酸激酶活性可直接比较正常和变异的abl基因产物。
Mol Cell Biol. 1985 Nov;5(11):3116-23. doi: 10.1128/mcb.5.11.3116-3123.1985.