Department of Neurosurgery and Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
Department of Neuropathology, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
Acta Neurochir (Wien). 2022 Apr;164(4):1105-1110. doi: 10.1007/s00701-021-05065-x. Epub 2021 Nov 20.
A nuclear protein of testis (NUT) carcinoma, also known as NUT midline carcinoma, is a rare subtype of squamous carcinoma known for its aggressive growth behaviour. It can form anywhere in the body. Although, it usually occurs along midline structures (head, neck, lungs). The authors present the first report of intrasellar NUT carcinoma with cavernous sinus infiltration in a 47-year-old patient. MRI showed an inhomogeneous, gadolinium-enhancing lesion with intra- and suprasellar growth, invasion of the cavernous sinus without clear differentiation from normal pituitary tissue. Given the lymphoma diagnosis in the frozen section and invasion of the cavernous sinus, the patient underwent endoscopic, transnasal, and transsphenoidal subtotal resection only. Local tumour and spinal metastases showed a good response to radio-chemotherapy. Despite combined radio-chemotherapy, the patient died of pulmonary insufficiency due to rapid progression of pulmonary metastasis 6 months after the initial diagnosis.
睾丸核蛋白（NUT）癌，也称为 NUT 中线癌，是一种罕见的鳞状细胞癌亚型，以其侵袭性生长行为而闻名。它可以在身体的任何部位形成。尽管它通常发生在中线结构（头部、颈部、肺部）中。作者报告了首例鞍内 NUT 癌伴海绵窦浸润的病例，患者为 47 岁男性。MRI 显示不均匀、钆增强病变，鞍内和鞍上生长，侵犯海绵窦，与正常垂体组织无明显分界。鉴于冷冻切片诊断为淋巴瘤且侵犯海绵窦，患者仅接受了内镜经鼻蝶窦次全切除术。局部肿瘤和脊柱转移对放化疗反应良好。尽管进行了联合放化疗，但患者在初始诊断后 6 个月因肺部转移快速进展而死于肺功能不全。
