不同病因肝病患者的磷脂酰乙醇：六种同系物分析及与其他酒精标志物的比较

Phosphatidylethanol in patients with liver diseases of different etiologies: Analysis of six homologues and comparison with other alcohol markers.

作者信息

Aboutara Nadine, Szewczyk Anne, Jungen Hilke, Mosebach Amadea, Rodriguez Lago Maria, Vettorazzi Eik, Iwersen-Bergmann Stefanie, Müller Alexander, Sterneck Martina

机构信息

Department of Legal Medicine, University Medical Centre Hamburg-Eppendorf, Butenfeld 34, 22529 Hamburg, Germany.

出版信息

Clin Chim Acta. 2022 Jan 1;524:171-178. doi: 10.1016/j.cca.2021.11.013. Epub 2021 Nov 19.

DOI:10.1016/j.cca.2021.11.013

PMID:34801484

Abstract

BACKGROUND AND AIMS

Phosphatidylethanol (PEth) is a direct alcohol biomarker. Aim of the study was to evaluate the performance of six homologues of PEth in comparison to other alcohol markers in patients with liver diseases.

METHODS

The study included 234 patients with liver disease, who gave statements about alcohol consumption during the three months prior to the doctor's appointment. Ethylglucuronide in urine (uEtG) and in hair (hEtG) and carbohydrate-deficient transferrin (CDT) were analyzed in addition to PEth.

RESULTS

Of all patients 47% stated to have drunk alcohol during the past three months. UEtG, hEtG and CDT showed a sensitivity of 29% and a specificity of 92% together for ingestion of at least two standard drinks (24 g) per week. With PEth 16:0/18:1 in addition, sensitivity increased to 59%. For consumption in the last week uEtG's sensitivity and specificity was 28% and 100%, respectively. PEth's was 75% and 93%. When looking at patients who consumed at least two standard drinks per week during the past three months and of which a hair sample could be obtained, hEtG's sensitivity was 37% and specificity 90%. PEth had a sensitivity of 53% and specificity of 100%. Quotients of PEth 16:0/18:1 with 16:0/18:2, 16:0/20:4 and 18:0/18:2 were smaller when alcohol had been consumed more recently.

CONCLUSION

Despite the rather poor overall sensitivity of alcohol biomarkers in this study, PEth showed best sensitivity for all time periods of alcohol consumption.

摘要

背景与目的

磷脂酰乙醇（PEth）是一种直接的酒精生物标志物。本研究的目的是评估六种PEth同系物与其他酒精标志物相比在肝病患者中的性能。

方法

该研究纳入了234例肝病患者，这些患者在预约看医生前三个月内提供了饮酒情况的说明。除了PEth外，还分析了尿液（uEtG）和头发（hEtG）中的乙基葡萄糖醛酸苷以及缺糖转铁蛋白（CDT）。

结果

在所有患者中，47%表示在过去三个月内饮酒。对于每周至少摄入两杯标准饮品（24克）的情况，uEtG、hEtG和CDT的总体敏感性为29%，特异性为92%。加上PEth 16:0/18:1后，敏感性提高到59%。对于上周的饮酒情况，uEtG的敏感性和特异性分别为28%和100%，PEth的敏感性和特异性分别为75%和93%。在过去三个月内每周至少饮用两杯标准饮品且能获取头发样本的患者中，hEtG的敏感性为37%，特异性为90%。PEth的敏感性为53%，特异性为100%。最近饮酒时，PEth 16:0/18:1与16:0/18:2、16:0/20:4和18:0/18:2的比值较小。