Rana Tarapati, Behl Tapan, Sehgal Aayush, Singh Sukhbir, Sharma Neelam, Abdeen Ahmed, Ibrahim Samah F, Mani Vasudevan, Iqbal Muhammad Shahid, Bhatia Saurabh, Abdel Daim Mohamed M, Bungau Simona
Chitkara College of Pharmacy, Chitkara University, Punjab, India; Government Pharmacy College, Seraj, Mandi, Himachal Pradesh, India.
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 2;114:110478. doi: 10.1016/j.pnpbp.2021.110478. Epub 2021 Nov 18.
Depression is one of the most prevalent forms of mental disorders and is the most common cause of disability in the Western world. Besides, the harmful effects of stress-related mood disorders on the patients themselves, they challenge the health care system with enormous social and economic impacts. Due to the high proportion of patients not responding to existing drugs, finding new treatment strategies has become an important topic in neurobiology, and there is much evidence that neuropeptides are not only involved in the physiology of stress but may also be clinically important. Based on preclinical trial data, new neuropharmaceutical candidates may target neuropeptides and their receptors and are expected to be essential and valuable tools in the treatment of psychiatric disorders. In the current article, we have summarized data obtained from animal models of depressive disorder and transgenic mouse models. We also focus on previously published research data of clinical studies on corticotropin-releasing hormone (CRH), galanin (GAL), neuropeptide Y (NPY), neuropeptide S (NPS), Oxytocin (OXT), vasopressin (VP), cholecystokinin (CCK), and melanin-concentrating hormone (MCH) stress research fields.
抑郁症是最常见的精神障碍形式之一，也是西方世界致残的最常见原因。此外，与压力相关的情绪障碍不仅对患者自身有有害影响，还对医疗保健系统构成挑战，产生巨大的社会和经济影响。由于很大一部分患者对现有药物没有反应，寻找新的治疗策略已成为神经生物学中的一个重要课题，而且有很多证据表明神经肽不仅参与应激生理过程，在临床上可能也很重要。基于临床前试验数据，新的神经药物候选物可能以神经肽及其受体为靶点，有望成为治疗精神疾病的重要且有价值的工具。在本文中，我们总结了从抑郁症动物模型和转基因小鼠模型中获得的数据。我们还重点关注了先前发表的关于促肾上腺皮质激素释放激素（CRH）、甘丙肽（GAL）、神经肽Y（NPY）、神经肽S（NPS）、催产素（OXT）、加压素（VP）、胆囊收缩素（CCK）和促黑素细胞激素（MCH）应激研究领域的临床研究数据。
