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急性四肢骨折患儿全身麻醉前胃内容物评估:一项超声观察性队列研究。

Assessing gastric contents in children before general anesthesia for acute extremity fracture: An ultrasound observational cohort study.

作者信息

Evain Jean-Noël, Durand Zoé, Dilworth Kelly, Sintzel Sarah, Courvoisier Aurélien, Mortamet Guillaume, Desgranges François-Pierrick, Bouvet Lionel, Payen Jean-François

机构信息

Department of Anesthesia and Intensive Care, Grenoble-Alpes University Hospital, CS 10217, 38043 Grenoble Cedex 9, France.

Department of Anesthesia and Intensive Care, Grenoble-Alpes University Hospital, CS 10217, 38043 Grenoble Cedex 9, France.

出版信息

J Clin Anesth. 2022 May;77:110598. doi: 10.1016/j.jclinane.2021.110598. Epub 2021 Nov 18.

Abstract

STUDY OBJECTIVE

Children with acute extremity fractures are commonly considered to be at risk of pulmonary aspiration of gastric contents during the induction of anesthesia. This study aimed to evaluate the proportion of such children with high-risk gastric contents using preoperative gastric ultrasound.

DESIGN

Prospective observational cohort study.

SETTING

Specialist pediatric center over a 30-month period.

PATIENTS

Children undergoing surgery within 24 h of an acute extremity fracture.

INTERVENTIONS

None.

MEASUREMENTS

According to preoperative qualitative and quantitative ultrasound analysis of the antrum in the supine and right lateral decubitus positions, gastric contents were classified as high-risk (clear liquid with calculated gastric fluid volume > 0.8 mL.kg, thick liquid, or solid) or low-risk. Factors associated with high-risk gastric contents were identified by multivariable analysis.

MAIN RESULTS

Forty-one children (37%; 95% CI: 28-47) of the 110 studied (mean(SD) age: 10(3) years) presented with high-risk gastric contents, including 26 (24%; 95% CI: 16-33) with solids/thick liquid contents. Scanning in the supine position alone allowed a diagnosis of high-risk gastric contents in 23 children out of the 63 for whom right lateral decubitus positioning was unfeasible. Gastric contents remained undetermined in 41 children, including one with a non-contributory gastric US (antrum non-visualized). Proximal limb fractures (OR: 2.5; 95% CI: 1.0-6.2), preoperative administration of opioids (OR: 3.9; 95% CI: 1.1-13), and the absence of bowel sounds (OR: 8.0; 95% CI: 1.4-44) were associated with high-risk gastric contents. Performing surgery the day following the trauma was a protective factor (OR: 0.1; 95% CI: 0.0-0.6). No cases of pulmonary aspiration occurred.

CONCLUSIONS

At least one-third of children with an acute isolated extremity fracture had preoperative gastric contents identified as high risk for pulmonary aspiration. Although preoperative history can guide anesthetic strategy in this population, ultrasound allowed clear stratification of the risk of aspiration in most cases.

摘要

研究目的

急性四肢骨折患儿在麻醉诱导期间通常被认为有胃内容物肺误吸的风险。本研究旨在通过术前胃超声评估此类高危胃内容物患儿的比例。

设计

前瞻性观察队列研究。

地点

在一个专科儿科中心,为期30个月。

患者

急性四肢骨折后24小时内接受手术的儿童。

干预措施

无。

测量方法

根据术前对仰卧位和右侧卧位胃窦的定性和定量超声分析,将胃内容物分为高危(清亮液体且计算出的胃液量>0.8 mL/kg、浓稠液体或固体)或低危。通过多变量分析确定与高危胃内容物相关的因素。

主要结果

在110名研究对象(平均(标准差)年龄:10(3)岁)中,41名儿童(37%;95%置信区间:28-47)呈现高危胃内容物,其中26名(24%;95%置信区间:16-33)为固体/浓稠液体内容物。对于63名无法进行右侧卧位定位的儿童,仅仰卧位扫描就诊断出23名高危胃内容物患儿。41名儿童的胃内容物仍无法确定,其中1名胃超声无诊断价值(胃窦未显示)。近端肢体骨折(比值比:2.5;95%置信区间:1.0-6.2)、术前使用阿片类药物(比值比:3.9;95%置信区间:1.1-13)以及无肠鸣音(比值比:8.0;95%置信区间:1.4-44)与高危胃内容物相关。创伤后第二天进行手术是一个保护因素(比值比:0.1;95%置信区间:0.0-0.6)。未发生肺误吸病例。

结论

至少三分之一的急性孤立性四肢骨折患儿术前胃内容物被确定为肺误吸高危。虽然术前病史可指导该人群的麻醉策略,但在大多数情况下,超声能清晰地对误吸风险进行分层。

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