Fan Wenwen, Cheng Yi, Zhao Haili, Yang Shaoxiong, Wang Longjie, Zheng Liyan, Cao Qiu'e, Fan W, Cheng Y, Zhao H, Yang S, Wang L, Zheng L, Cao Q
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education Functional Molecules Analysis and Biotransformation, Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, No. 2 North Cuihu Road, Kunming, 650091, PR China.
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education Functional Molecules Analysis and Biotransformation, Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, No. 2 North Cuihu Road, Kunming, 650091, PR China.
Talanta. 2022 Feb 1;238(Pt 2):123030. doi: 10.1016/j.talanta.2021.123030. Epub 2021 Nov 8.
The development of analytical method for selective and sensitive detection of gossypol (Gsp), an extraction from the cotton plants, is important but still challenging in food safety and medical field. Herein, we reported a turn-on near infrared (NIR) fluorescence detection strategy for Gsp based on a metal-organic framework (MOF), QBA-Yb, which was prepared from 4,4'-(quinolone-5, 8-diyl) benzoate with Yb(NO)·5HO by solvothermal synthesis. The Gsp acted as another "antenna" to sensitize the luminescence of Yb, leading to the turn-on NIR emission upon 467 nm excitation. As Gsp concentration increased, the NIR emission at 973 nm enhanced gradually, thus enabling highly sensitive Gsp detection in a turn-on way. The experiment and theoretical calculation results revealed the presence of strong hydrogen bonds between Gsp molecules and the MOF skeleton. The developed QBA-Yb probe showed excellent characteristics for detection of Gsp molecules, accompanied by wide linear range (5-160 μg/mL), low detection limit (0.65 μg/mL) and short response time (within 10 min). We have further demonstrated that the QBA-Yb probe was successfully applied for the determination of Gsp in real samples of cottonseeds.
棉籽提取物棉酚（Gsp）选择性和灵敏检测分析方法的开发在食品安全和医学领域至关重要，但仍具有挑战性。在此，我们报道了一种基于金属有机框架（MOF）QBA-Yb的开启型近红外（NIR）荧光检测策略，该MOF由4,4'-（喹啉-5,8-二基）苯甲酸酯与Yb(NO)·5HO通过溶剂热合成法制备。Gsp作为另一个“天线”敏化Yb的发光，在467nm激发下导致开启型近红外发射。随着Gsp浓度增加，973nm处的近红外发射逐渐增强，从而能够以开启方式对Gsp进行高灵敏检测。实验和理论计算结果表明Gsp分子与MOF骨架之间存在强氢键。所开发的QBA-Yb探针在检测Gsp分子方面表现出优异特性，具有宽线性范围（5-160μg/mL）、低检测限（0.65μg/mL）和短响应时间（10分钟内）。我们进一步证明QBA-Yb探针成功应用于棉籽实际样品中Gsp的测定。
