Rollag H, Evensen S A, Frøland S S, Glomstein A
Institute of Bacteriology, Rikshospitalet, Oslo, Norway.
Eur J Haematol. 1987 Oct;39(4):353-5. doi: 10.1111/j.1600-0609.1987.tb00782.x.
Serial serum samples from the 21 HIV-infected Norwegian hemophiliacs have been assayed for the presence of HIV antigen and antibodies to HIV specific for the core protein p24 and the envelope protein gp41. HIV antigen was detected in 4 patients, of whom 3 have developed AIDS to date. HIV antigen appeared in serum 10 to 24 months before the diagnosis in these patients. Antibodies to gp41 was a constant finding. Antibodies to p24 disappeared from the serum in 1 patient who developed AIDS and from 3 persons free of symptoms related to the HIV infection. The detection of HIV antigen in HIV antibody-positive hemophiliacs appears to be of considerable prognostic significance.
对21名感染了HIV的挪威血友病患者的系列血清样本进行了检测，以确定是否存在HIV抗原以及针对核心蛋白p24和包膜蛋白gp41的HIV特异性抗体。在4名患者中检测到了HIV抗原，其中3名患者至今已发展为艾滋病。在这些患者中，HIV抗原在诊断前10至24个月出现在血清中。针对gp41的抗体是一个持续的发现。在1名发展为艾滋病的患者以及3名无HIV感染相关症状的人中，血清中针对p24的抗体消失了。在HIV抗体阳性的血友病患者中检测到HIV抗原似乎具有相当大的预后意义。
