Department of Blood Transfusion, Fujian Medical University Union Hospital, Gulou District, Fuzhou City, 350001, Fujian Province, China.
Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Department of Hematology, Fujian Medical University Union Hospital, Gulou District, Fuzhou City, 350001, Fujian Province, China.
BMC Cancer. 2021 Nov 21;21(1):1255. doi: 10.1186/s12885-021-08963-6.
Fatty acid metabolism is reportedly associated with various cancers. However, the role of pretreatment serum free fatty acid (FFA) levels in diffuse large B-cell lymphoma (DLBCL) prognosis is still unclear, and our study aimed to better elucidate its influence on clinical outcomes.
The medical records of 221 newly diagnosed DLBCL patients admitted to Fujian Medical University Union Hospital from January 2011 to December 2016 were analysed retrospectively. Receiver operating characteristic curve analysis was used to determine a cut-off value for pretreatment serum FFA levels for prognostic prediction in DLBCL patients. The relationship between pretreatment serum FFA levels and clinical and laboratory parameters was analysed. Univariate and multivariate analyses were used to assess prognostic factors for overall survival (OS) and progression-free survival (PFS).
Newly diagnosed DLBCL patients with high pretreatment serum FFA levels (≥0.495 mmol/l) had more B symptoms, higher serum lactate dehydrogenase levels (> upper limit of normal), >1 extranodal site, and higher International Prognostic Index score (3-5) compared to those with low pretreatment serum FFA levels (<0.495 mmol/l). Higher serum FFA levels were independent prognostic factors for poor OS, but not PFS.
High pretreatment serum FFA levels are associated with lower survival in untreated DLBCL patients.
脂肪酸代谢与多种癌症有关。然而，预处理血清游离脂肪酸（FFA）水平在弥漫性大 B 细胞淋巴瘤（DLBCL）预后中的作用尚不清楚，我们的研究旨在更好地阐明其对临床结局的影响。
回顾性分析 2011 年 1 月至 2016 年 12 月福建医科大学附属协和医院收治的 221 例初诊 DLBCL 患者的病历。采用受试者工作特征曲线分析确定预测 DLBCL 患者预后的预处理血清 FFA 水平的截断值。分析预处理血清 FFA 水平与临床和实验室参数之间的关系。采用单因素和多因素分析评估总生存（OS）和无进展生存（PFS）的预后因素。
与低预处理血清 FFA 水平（<0.495mmol/L）的患者相比，新诊断的 DLBCL 患者中，高预处理血清 FFA 水平（≥0.495mmol/L）患者具有更多的 B 症状、更高的血清乳酸脱氢酶水平（>正常值上限）、>1 个结外部位和更高的国际预后指数评分（3-5）。较高的血清 FFA 水平是 OS 不良的独立预后因素，但不是 PFS 的独立预后因素。
未经治疗的 DLBCL 患者中，高预处理血清 FFA 水平与较低的生存率相关。
