Department of Pathology, Cancer Institute University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA.
Department of Data Science, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Lipids Health Dis. 2019 Nov 3;18(1):189. doi: 10.1186/s12944-019-1130-4.
It remains controversial whether and which fatty acids are different between prostate cancer (PCa) and benign prostatic tissues (BPT) in association with occurrence, progression and racial disparity between African American (AA) and Caucasian American (CA) populations.
Total fatty acids (TFA) and free fatty acid (FFA) were determined on fresh frozen prostatic tissues including 26 PCa and 21 BPT from AA and CA patients by Gas chromatography with flame ionization detection (GC-FID) and Electrospray Ionization Mass Spectrometry (ESI-MS), respectively.
In all studied population, TFA in 8 out of 16 individual species, in total and in groups of saturated total fatty acid (STFA), mono-unsaturated total fatty acid (MUTFA), poly-unsaturated total fatty acid (PUTFA) and n-6 TFA were significantly higher in PCa than in BPT; FFA in 4 out of 10 individual species, in total and in groups of MUFFA, PUFFA, n-6 FFA and n-3 FFA were significantly higher in PCa than in BPT. The concentrations of most fatty acid parameters correlated with Gleason's grade and clinical stage of PCa. As compared with CA men, AA men had higher concentrations of TFA, especially TFA with chains of 14-18 carbons than in BPT, and lower concentrations of TFA in PCa.
Increasing in prostatic fatty acids in the form of TFA and FFA correlated to occurrence, progression and racial disparity of PCa.
前列腺癌（PCa）和良性前列腺组织（BPT）之间的脂肪酸是否存在差异，以及这种差异与非裔美国人（AA）和高加索裔美国人（CA）人群之间的发生、进展和种族差异有何关联，目前仍存在争议。
通过气相色谱-火焰离子化检测（GC-FID）和电喷雾电离质谱（ESI-MS）分别对来自 AA 和 CA 患者的 26 例 PCa 和 21 例 BPT 的新鲜冷冻前列腺组织中的总脂肪酸（TFA）和游离脂肪酸（FFA）进行了测定。
在所研究的所有人群中，16 种脂肪酸中的 8 种，以及饱和总脂肪酸（STFA）、单不饱和总脂肪酸（MUTFA）、多不饱和总脂肪酸（PUTFA）和 n-6 总脂肪酸的总量和分组中，TFA 在 PCa 中的含量明显高于 BPT；10 种脂肪酸中的 4 种，以及 MUFFA、PUFFA、n-6 FFA 和 n-3 FFA 的总量和分组中，FFA 在 PCa 中的含量明显高于 BPT。大多数脂肪酸参数的浓度与 PCa 的 Gleason 分级和临床分期相关。与 CA 男性相比，AA 男性的 TFA 浓度更高，尤其是 BPT 中的 14-18 碳链 TFA 浓度更高，而 PCa 中的 TFA 浓度更低。
前列腺中 TFA 和 FFA 形式的脂肪酸的增加与 PCa 的发生、进展和种族差异有关。
