Wan Huijuan, Wang Xing, Chen Yiyi, Jiang Bin, Chen Yangmei, Hu Wenhan, Zhang Kai, Shao Xiaoqiu
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, People's Republic of China.
Nat Sci Sleep. 2021 Nov 13;13:2065-2084. doi: 10.2147/NSS.S330986. eCollection 2021.
Sleep-related hypermotor epilepsy (SHE) is a group of clinical syndromes with heterogeneous etiologies. SHE is difficult to diagnose and treat in the early stages due to its diverse clinical manifestations and difficulties in differentiating from non-epileptic events, which seriously affect patients' quality of life and social behavior. The overall prognosis for SHE is unsatisfactory, but different etiologies affect patients' prognoses. Surgical treatment is an effective method for carefully selected patients with refractory SHE; nevertheless, preoperative assessment remains challenging because of the low sensitivity of noninvasive scalp electroencephalogram and imaging to detect abnormalities. However, through a careful analysis of semiology, the clinician can deduce the potential epileptogenic zone. This paper summarizes the research status of the background, etiology, electro-clinical features, diagnostic criteria, prognosis, and treatment of SHE to provide a more in-depth understanding of its pathophysiological mechanism, improve the accuracy in the diagnosis of this group of syndromes, and further explore more targeted therapy plans.
睡眠相关运动过多性癫痫（SHE）是一组病因各异的临床综合征。由于其临床表现多样且难以与非癫痫性事件相鉴别，SHE在早期难以诊断和治疗，这严重影响了患者的生活质量和社会行为。SHE的总体预后并不理想，但不同病因会影响患者的预后。手术治疗是精心挑选的难治性SHE患者的有效方法；然而，由于无创头皮脑电图和影像学检测异常的敏感性较低，术前评估仍然具有挑战性。然而，通过仔细分析症状学，临床医生可以推断出潜在的致痫区。本文总结了SHE的背景、病因、电临床特征、诊断标准、预后及治疗的研究现状，以更深入地了解其病理生理机制，提高对这组综合征的诊断准确性，并进一步探索更具针对性的治疗方案。
