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预测输卵管因素不孕、多囊卵巢综合征或子宫内膜异位症患者受精周期中囊胚形成率的列线图的发展。

The Development of Nomograms to Predict Blastulation Rate Following Cycles of Fertilization in Patients With Tubal Factor Infertility, Polycystic Ovary Syndrome, or Endometriosis.

机构信息

Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

Front Endocrinol (Lausanne). 2021 Nov 3;12:751373. doi: 10.3389/fendo.2021.751373. eCollection 2021.

Abstract

It is well known that the transfer of embryos at the blastocyst stage is superior to the transfer of embryos at the cleavage stage in many respects. However, the rate of blastocyst formation remains low in clinical practice. To reduce the possibility of wasting embryos and to accurately predict the possibility of blastocyst formation, we constructed a nomogram based on range of clinical characteristics to predict blastocyst formation rates in patients with different types of infertility. We divided patients into three groups based on female etiology: a tubal factor group, a polycystic ovary syndrome group, and an endometriosis group. Multiple logistic regression was used to analyze the relationship between patient characteristics and blastocyst formation. Each group of patients was divided into a training set and a validation set. The training set was used to construct the nomogram, while the validation set was used to test the performance of the model by using discrimination and calibration. The area under the curve (AUC) for the three groups indicated that the models performed fairly and that calibration was acceptable in each model.

摘要

众所周知,在许多方面,囊胚期胚胎移植优于卵裂期胚胎移植。然而,囊胚形成率在临床实践中仍然较低。为了减少浪费胚胎的可能性,并准确预测囊胚形成的可能性,我们根据一系列临床特征构建了一个列线图,以预测不同类型不孕患者的囊胚形成率。我们根据女性病因将患者分为三组:输卵管因素组、多囊卵巢综合征组和子宫内膜异位症组。多因素逻辑回归分析了患者特征与囊胚形成之间的关系。将每组患者分为训练集和验证集。训练集用于构建列线图,而验证集用于通过判别和校准来测试模型的性能。三组的曲线下面积(AUC)表明,模型表现相当,并且每个模型的校准都是可以接受的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57af/8595301/b03c8fafcbce/fendo-12-751373-g001.jpg

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