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Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles.在新鲜供体卵母细胞体外受精周期中，卵母细胞和受精卵的总数可预测活产妊娠。
Fertil Steril. 2017 Aug;108(2):262-268. doi: 10.1016/j.fertnstert.2017.05.021. Epub 2017 Jun 7.
2
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本文引用的文献

1
Donor TSH level is associated with clinical pregnancy among oocyte donation cycles.在卵母细胞捐赠周期中，供体促甲状腺激素水平与临床妊娠相关。
J Assist Reprod Genet. 2016 Apr;33(4):489-94. doi: 10.1007/s10815-016-0668-6. Epub 2016 Feb 4.
2
Reproductive outcomes in oocyte donation cycles are associated with donor BMI.卵母细胞捐赠周期中的生殖结局与供体体重指数相关。
Hum Reprod. 2016 Feb;31(2):385-92. doi: 10.1093/humrep/dev298. Epub 2015 Dec 17.
3
Predicting the chance of live birth for women undergoing IVF: a novel pretreatment counselling tool.预测接受体外受精的女性的活产几率：一种新型的预处理咨询工具。
Hum Reprod. 2016 Jan;31(1):84-92. doi: 10.1093/humrep/dev268. Epub 2015 Oct 25.
4
Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.回收卵母细胞数量与活产率及出生体重的关联：对231,815个体外受精周期的分析
Fertil Steril. 2015 Apr;103(4):931-938.e2. doi: 10.1016/j.fertnstert.2014.12.120. Epub 2015 Jan 28.
5
Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256,381 in vitro fertilization cycles.卵母细胞数量作为卵巢过度刺激综合征和活产预测指标的分析：256381 个体外受精周期。
Fertil Steril. 2014 Apr;101(4):967-73. doi: 10.1016/j.fertnstert.2013.12.026. Epub 2014 Jan 23.
6
Donor age is a major determinant of success of oocyte donation/recipient programme.供卵者的年龄是卵母细胞捐赠/受者计划成功的主要决定因素。
Hum Reprod. 2012 Jan;27(1):118-25. doi: 10.1093/humrep/der359. Epub 2011 Nov 2.
7
How many eggs are needed to produce an assisted reproductive technology baby: is more always better?进行辅助生殖技术治疗需要多少枚卵子：是不是越多越好？
Fertil Steril. 2011 Aug;96(2):332-5. doi: 10.1016/j.fertnstert.2011.05.099. Epub 2011 Jun 30.
8
Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles.体外受精治疗中卵子数量与活产率的关系：对 400135 个治疗周期的分析。
Hum Reprod. 2011 Jul;26(7):1768-74. doi: 10.1093/humrep/der106. Epub 2011 May 10.
9
Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes.多变量分析卵母细胞供体特征（包括基础卵泡刺激素（FSH）和年龄）与体外受精周期结局的关系。
Fertil Steril. 2010 Sep;94(4):1292-1295. doi: 10.1016/j.fertnstert.2009.07.1672. Epub 2009 Oct 12.
10
Optimum number of oocytes for a successful first IVF treatment cycle.首次体外受精治疗周期成功所需的最佳卵母细胞数量。
Reprod Biomed Online. 2006 Oct;13(4):476-80. doi: 10.1016/s1472-6483(10)60633-5.

在新鲜供体卵母细胞体外受精周期中，卵母细胞和受精卵的总数可预测活产妊娠。

Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles.

作者信息

Hariton Eduardo, Kim Keewan, Mumford Sunni L, Palmor Marissa, Bortoletto Pietro, Cardozo Eden R, Karmon Anatte E, Sabatini Mary E, Styer Aaron K

机构信息

Vincent Department of Obstetrics and Gynecology, Reproductive Medicine and IVF, Massachusetts General Hospital, Boston, Massachusetts; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

出版信息

Fertil Steril. 2017 Aug;108(2):262-268. doi: 10.1016/j.fertnstert.2017.05.021. Epub 2017 Jun 7.

DOI:10.1016/j.fertnstert.2017.05.021
PMID:28601410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5545054/
Abstract

OBJECTIVE

To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET.

DESIGN

Retrospective cohort study.

SETTING

Academic reproductive medicine practice.

PATIENT(S): Two hundred thirty-seven consecutive fresh donor oocyte IVF-ET cycles from January 1, 2007 to December 31, 2013 at the Massachusetts General Hospital Fertility Center.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Live birth rate per cycle initiated.

RESULT(S): The mean (±SD) age of oocyte donors and recipients was 27.0 ± 3.7 and 41.4 ± 4.6 years, respectively. Oocyte donor demographic/reproductive characteristics, ovarian reserve testing, and peak serum E during ovarian stimulation were similar among cycles which did and did not result in live birth, respectively. Overall implantation, clinical pregnancy, and live birth pregnancy rates per cycle initiated were 40.5%, 60.8%, and 54.9%, respectively. The greatest probability of live birth was observed in cycles with >10 oocytes retrieved, mature oocytes, oocytes with normal fertilization (zygote-two pronuclear stage), and cleaved embryos.

CONCLUSION(S): The number of oocytes (total and mature), zygotes, and cleaved embryos are associated with live birth following donor oocyte IVF cycles. These findings suggest that specific peri-fertilization factors may be predictive of pregnancy outcomes following donor oocyte IVF cycles.

摘要

目的

评估卵母细胞供受者特征、卵母细胞供者反应以及新鲜供者卵母细胞体外受精-胚胎移植（IVF-ET）后的活产妊娠率之间的关联。

设计

回顾性队列研究。

地点

学术性生殖医学机构。

患者

2007年1月1日至2013年12月31日期间在马萨诸塞州综合医院生育中心进行的237例连续新鲜供者卵母细胞IVF-ET周期。

干预措施

无。

主要观察指标

每个启动周期的活产率。

结果

卵母细胞供者和受者的平均（±标准差）年龄分别为27.0±3.7岁和41.4±4.6岁。分别在活产和未活产的周期中，卵母细胞供者的人口统计学/生殖特征、卵巢储备检测以及卵巢刺激期间的血清E峰值相似。每个启动周期的总体着床率、临床妊娠率和活产妊娠率分别为40.5%、60.8%和54.9%。在回收>10个卵母细胞、成熟卵母细胞、受精正常（受精卵-双原核期）的卵母细胞以及分裂胚的周期中观察到最高的活产概率。

结论

卵母细胞（总数和成熟数）、受精卵和分裂胚的数量与供者卵母细胞IVF周期后的活产相关。这些发现表明特定的受精周围因素可能预测供者卵母细胞IVF周期后的妊娠结局。