Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Comput Math Methods Med. 2021 Nov 12;2021:2867913. doi: 10.1155/2021/2867913. eCollection 2021.
To study the clinical features of infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) mixed with Mycoplasma pneumonia (MP) or/and cytomegalovirus (CMV)infection, collected 201 hospitalized children who met the IM diagnostic criteria, the clinical manifestations, laboratory tests, complications, treatment, and outcome were compared among EBV infection alone and EBV mixed with MP or/and CMV infection. Most of the children with IM were preschoolers, more frequently occurred in boys than girls. EBV patients with MP had the longest duration of fever. When mixed pathogen infections were involved, the white blood cell count of preschool children was significantly increased, while splenomegaly was more common in older children. In the cases of EBV infection alone, abnormal liver function was positively correlated with age ( = 0.044). Mixed pathogen infections were more common in children with IM, occurring in all age groups, and some clinical characteristics were related to the age of onset and the pathogen of the infection.
为了研究由 Epstein-Barr 病毒（EBV）与肺炎支原体（MP）或/和巨细胞病毒（CMV）混合感染引起的传染性单核细胞增多症（IM）的临床特征，收集了 201 名符合 IM 诊断标准的住院患儿，比较了 EBV 单独感染和 EBV 与 MP 或/和 CMV 混合感染患儿的临床表现、实验室检查、并发症、治疗和转归。大多数 IM 患儿为学龄前儿童，男孩多于女孩。EBV 合并 MP 感染的患儿发热时间最长。当混合病原体感染时，学龄前儿童的白细胞计数明显升高，而年长儿更常见脾肿大。在 EBV 单独感染的病例中，肝功能异常与年龄呈正相关（ = 0.044）。混合病原体感染在 IM 患儿中更为常见，发生于所有年龄组，某些临床特征与发病年龄和感染病原体有关。
