Department of Ultrasound, The Eighth Medical Center, Chinese PLA General Hospital, Beijing, China.
Western Medical Distict of Chinese PLA General Hospital, Beijing, China.
J Healthc Eng. 2021 Nov 11;2021:5031667. doi: 10.1155/2021/5031667. eCollection 2021.
To explore the correlation between the resistance characteristics of (HP) and antibiotic use density (AUD) in a hospital from 2012 to 2018.
HP strains isolated from Chinese PLA General Hospital from 2012 to 2018 were collected to analyze the drug resistance of clarithromycin, levofloxacin, amoxicillin, and metronidazole, and their correlation with the AUD of the outpatient department and inpatient department was analyzed, respectively.
From 2012 to 2018, metronidazole-resistant strains accounted for the largest proportion, followed by clarithromycin and levofloxacin, and amoxicillin-resistant strains accounted for the least. In 2012-2018, the resistance rate of clarithromycin, levofloxacin, amoxicillin, and metronidazole has basically increased year by year; from 2012 to 2018, the highest outpatient AUD in a hospital was amoxicillin, followed by clarithromycin and levofloxacin, metronidazole was the lowest, and the inpatient AUD from high to low was levofloxacin, metronidazole, amoxicillin, and clarithromycin. The drug resistance rate of HP in the hospital from 2012 to 2018 was positively correlated with the AUD of clarithromycin ( = 0.884, =0.017) and levofloxacin ( = 0.934, =0.002) in the outpatient department.
has the strongest resistance to metronidazole and the worst resistance to amoxicillin in the hospital from 2012 to 2018, being related to the intensity of clarithromycin and levofloxacin in the outpatient department. It may provide certain reference significance for the clinical treatment of .
探讨 2012 年至 2018 年期间某医院幽门螺杆菌（HP）耐药性与抗生素使用密度（AUD）的相关性。
收集 2012 年至 2018 年中国人民解放军总医院分离的 HP 菌株，分析克拉霉素、左氧氟沙星、阿莫西林和甲硝唑的耐药性，并分别分析其与门诊和住院部 AUD 的相关性。
2012 年至 2018 年，甲硝唑耐药菌株所占比例最大，其次为克拉霉素和左氧氟沙星，阿莫西林耐药菌株所占比例最小。2012-2018 年，克拉霉素、左氧氟沙星、阿莫西林和甲硝唑的耐药率基本呈逐年上升趋势；2012 年至 2018 年，医院门诊 AUD 最高的是阿莫西林，其次是克拉霉素和左氧氟沙星，甲硝唑最低，住院 AUD 由高到低分别是左氧氟沙星、甲硝唑、阿莫西林和克拉霉素。2012 年至 2018 年医院 HP 耐药率与门诊克拉霉素（ = 0.884， =0.017）和左氧氟沙星（ = 0.934， =0.002）AUD 呈正相关。
2012 年至 2018 年期间，医院中 HP 对甲硝唑的耐药性最强，对阿莫西林的耐药性最差，与门诊克拉霉素和左氧氟沙星的强度有关。这可能为临床治疗 HP 提供一定的参考意义。
