Saeed Nermin Kamal, Al Khawaja Safaa, Al-Biltagi Mohammed
Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Manama, Bahrain.
Department of Internal Medicine, Salmaniya Medical Complex, Ministry of Health, Manama, Bahrain.
Oman Med J. 2021 Nov 10;36(6):e314. doi: 10.5001/omj.2021.95. eCollection 2021 Nov.
()-induced urinary tract infection (UTI) is a common infection associated with frequent use of antibiotics and the increase in global antibiotic resistances. We aimed to determine the susceptibility profile of extended-spectrum β-lactamase (ESBL) producing isolated from the urinary samples to fosfomycin and other antibiotics.
We retrospectively analyzed urine samples with ESBL-producing isolates obtained between January 2018 and December 2019 in the Microbiology Section, Salmaniya Medical Complex, Bahrain. We collected and analyzed all the urinary isolates' data and their antibiotic susceptibility patterns.
The study included 3044 isolates with 50.6% obtained in 2018 and 49.4% in 2019; 38.1% (1161 isolates) were ESBL and 0.7% (21 isolates) were carbapenem-resistant (CRE). There were 1161 (38.1%) isolates with ESBL-producing , with 37.3% isolated in 2018 and 39.0% isolated in 2019. The antibiotic susceptibility of ESBL-producing during the study period showed susceptibility to trimethoprim/sulfamethoxazole in 46.1% of isolates (50.2% in 2018 dropped to 41.9% in 2019), to ciprofloxacin in 49.0% of isolates (49.5% in 2018 dropped to 48.4% in 2019), to nitrofurantoin in 91.8% of isolates (94.3 in 2018 dropped to 89.3% in 2019), and to fosfomycin in 97.6% of isolates (98.8% in 2018 dropped to 96.3% in 2019).
ESBL-producing is an important cause of UTI in Bahrain. Fosfomycin is a very effective oral antimicrobial that retains high efficacy against ESBL-producing , which helps decrease the need for parenteral therapy and, consequently, hospitalization.
（）引起的尿路感染（UTI）是一种常见感染，与抗生素的频繁使用及全球抗生素耐药性增加相关。我们旨在确定从尿液样本中分离出的产超广谱β-内酰胺酶（ESBL）菌株对磷霉素及其他抗生素的敏感性情况。
我们回顾性分析了2018年1月至2019年12月期间在巴林萨尔曼尼亚医疗中心微生物科获得的产ESBL菌株的尿液样本。我们收集并分析了所有尿液分离株的数据及其抗生素敏感性模式。
该研究纳入了3044株分离株，2018年获得的占50.6%，2019年获得的占49.4%；38.1%（1161株）为产ESBL菌株，0.7%（21株）为耐碳青霉烯类菌株（CRE）。有1161株（38.1%）产ESBL菌株，2018年分离出37.3%，2019年分离出39.0%。研究期间产ESBL菌株的抗生素敏感性显示，46.1%的分离株对甲氧苄啶/磺胺甲恶唑敏感（2018年为50.2%，2019年降至41.9%），49.0%的分离株对环丙沙星敏感（2018年为49.5%，2019年降至48.4%），91.8%的分离株对呋喃妥因敏感（2018年为94.3%，2019年降至89.3%），97.6%的分离株对磷霉素敏感（2018年为98.8%，2019年降至96.3%）。
产ESBL菌株是巴林UTI的重要病因。磷霉素是一种非常有效的口服抗菌药物，对产ESBL菌株保持高疗效，这有助于减少肠外治疗需求，进而减少住院需求。
