Zhang Yina, Shao Jiajia, Li Shuangshuang, Liu Yanning, Zheng Min
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Oncol. 2021 Nov 5;11:775250. doi: 10.3389/fonc.2021.775250. eCollection 2021.
Hepatocellular carcinoma (HCC) is a highly lethal type of malignancies that possesses great loss of life safety to human beings worldwide. However, few effective means of curing HCC exist and its specific molecular basis is still far from being fully elucidated. Activation of nuclear factor kappa B (NF-κB), which is often observed in HCC, is considered to play a significant part in hepatocarcinogenesis and development. The emergence of regulatory non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is a defining advance in cancer biology, and related research in this branch has yielded many diagnostic and therapeutic opportunities. Recent studies have suggested that regulatory ncRNAs act as inhibitors or activators in the initiation and progression of HCC by targeting components of NF-κB signaling or regulating NF-κB activity. In this review, we attach importance to the role and function of regulatory ncRNAs in NF-κB signaling of HCC and NF-κB-associated chemoresistance in HCC, then propose future research directions and challenges of regulatory ncRNAs mediated-regulation of NF-κB pathway in HCC.
肝细胞癌（HCC）是一种高度致命的恶性肿瘤，对全球人类的生命安全构成巨大威胁。然而，目前治疗HCC的有效方法很少，其具体分子机制仍远未完全阐明。核因子κB（NF-κB）的激活在HCC中经常被观察到，被认为在肝癌发生和发展中起重要作用。调控性非编码RNA（ncRNAs）的出现，特别是微小RNA（miRNAs）和长链非编码RNA（lncRNAs），是癌症生物学的一个决定性进展，该领域的相关研究带来了许多诊断和治疗机会。最近的研究表明，调控性ncRNAs通过靶向NF-κB信号通路的组成部分或调节NF-κB活性，在HCC的发生和发展中起抑制或激活作用。在这篇综述中，我们重点关注调控性ncRNAs在HCC的NF-κB信号通路以及HCC中与NF-κB相关的化疗耐药中的作用和功能，然后提出调控性ncRNAs介导的HCC中NF-κB通路调控的未来研究方向和挑战。
