以致死性非创伤性脾破裂为表现的套细胞淋巴瘤。
Mantle cell lymphoma presenting with lethal atraumatic splenic rupture.
作者信息
Eyerer Frederick, Gardner Juli-Anne, Devitt Katherine A
机构信息
University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA.
University of Vermont, Larner College of Medicine, Burlington, VT, USA.
出版信息
Autops Case Rep. 2021 Nov 5;11:e2021340. doi: 10.4322/acr.2021.340. eCollection 2021.
Mantle cell lymphoma is characterized by t(11;14) with fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
套细胞淋巴瘤的特征是存在t(11;14) 及 融合，其临床表现的疾病谱范围从相对惰性到侵袭性。在此，我们报告一例具有三个融合信号的多形性套细胞淋巴瘤病例，该病例表现为致死性非创伤性脾破裂。我们讨论了CCND1变异信号模式的意义以及非创伤性脾破裂的流行病学和病理生理学。
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