Björck Erik, Landgren Ola, Schoumans Jacqueline, Christensson Birger, Björkholm Magnus, MacDonald Anna Porwit, Nordenskjöld Magnus
Department of Molecular Medicine, CMM L8:02 Karolinska Hospital and Institutet, SE-171 76, Stockholm, Sweden.
Leuk Lymphoma. 2003 Jul;44(7):1229-34. doi: 10.1080/1042819031000077061.
A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.
一名69岁女性因腹痛入院。检查发现脾脏肿大并进行了切除。组织学检查和流式细胞术分析无法明确区分脾边缘区淋巴瘤和套细胞淋巴瘤。运用分子细胞遗传学技术，发现了一种复杂的核型，其中包括11号和14号染色体之间的易位，这与重链免疫球蛋白基因座（IgH）和细胞周期蛋白D1（CCND1）之间的三联体融合一致。通过免疫染色检测到细胞周期蛋白D1的过表达。由此确诊为脾母细胞样套细胞淋巴瘤。本报告讨论了脾淋巴瘤鉴别诊断的各个方面。
