Lee Qiuyan, Yu Xixiang, Yu Weiwei
Wenzhou Medical University, Wenzhou, China.
Interventional Vascular surgery, Wenzhou people's Hospital, China.
J Interv Med. 2021 Mar 16;4(2):77-81. doi: 10.1016/j.jimed.2021.02.004. eCollection 2021 May.
To explore the diagnostic value of abnormal prothrombin Ⅱ (PIVKA-Ⅱ) and alpha-fetoprotein (AFP) in primary hepatocellular carcinoma (HCC).
From 2018 0.01 to 2020.01, there were 158 patients with primary liver cancer caused by chronic hepatitis B (male 116, women 42) and 62 patients with chronic hepatitis B (male 34, female 28). The levels of serum PIVKA-Ⅱ and AFP were measured, and the results were statistically analyzed.
The value of PIVKA-Ⅱin liver cancer group was distinctly higher than that in chronic viral hepatitis B group, the difference is statistically significant (P < 0.05). So does the value of AFP. Draw the subject working characteristic curve (ROC curve), the area under the curve of AFP and PIVKA-Ⅱ is 0.799 and 0.836, and that of the combination of AFP and PIVKA-Ⅱ is 0.854, the sensitivity is 57.6%,68.4%,72.2%,respectively, the specificity is 93.5%, 98.4%, 96.8%, respectively. After operation or interventional therapy, the value of PIVKA-Ⅱ in liver cancer group was clearly lower than that before treatment, and the difference was statistically significant.
In the diagnostic value of primary liver cancer, PIVKA-II combined with AFP is higher than PIVKA-II, while AFP has the lowest benefit. We also find that PIVKA-II has higher disease monitoring value than AFP.
探讨异常凝血酶原Ⅱ（PIVKA-Ⅱ）和甲胎蛋白（AFP）在原发性肝细胞癌（HCC）中的诊断价值。
选取2018年1月1日至2020年1月1日期间的158例慢性乙型肝炎所致原发性肝癌患者（男性116例，女性42例）以及62例慢性乙型肝炎患者（男性34例，女性28例）。检测血清PIVKA-Ⅱ和AFP水平，并对结果进行统计学分析。
肝癌组PIVKA-Ⅱ值明显高于慢性乙型病毒性肝炎组，差异具有统计学意义（P＜0.05）。AFP值亦是如此。绘制受试者工作特征曲线（ROC曲线），AFP和PIVKA-Ⅱ的曲线下面积分别为0.799和0.836，AFP与PIVKA-Ⅱ联合检测的曲线下面积为0.854，敏感性分别为57.6%、68.4%、72.2%，特异性分别为93.5%、98.4%、96.8%。手术或介入治疗后，肝癌组PIVKA-Ⅱ值明显低于治疗前，差异具有统计学意义。
在原发性肝癌的诊断价值方面，PIVKA-II联合AFP高于PIVKA-II，而AFP单独检测的诊断效能最低。我们还发现，PIVKA-II在疾病监测方面的价值高于AFP。
