Division of Neonatal-Perinatal Medicine, Department of Pediatrics, C.S. Mott Children's Hospital, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
J Neonatal Perinatal Med. 2022;15(3):659-662. doi: 10.3233/NPM-210851.
Breast milk feeding is an important late-onset sepsis reduction strategy in the Neonatal Intensive Care Unit (NICU). However, multiple studies have reported transfer of bacteria-contaminated breast milk to infants. We describe a case of culture-positive breast milk resulting in persistent Enterococcus bacteremia in an infant. Beyond the development of an infant's innate and specific immunity as well as colonization of the gastrointestinal (GI) tract with commensal organisms, the risk of bacterial translocation from the GI tract into the bloodstream is shaped and modified by maternal health, birth history, and an infant's NICU course. While freezing and/or pasteurizing breast milk reduces or eliminates its bacterial load, it also diminishes its immunologic and nutritional benefits.
母乳喂养是新生儿重症监护病房(NICU)中减少晚期败血症的重要策略。然而,多项研究报告称,母乳中会转移细菌污染。我们描述了一例因细菌污染的母乳导致婴儿持续肠球菌血症的病例。除了婴儿先天和特异性免疫的发展以及胃肠道(GI)道中共生体的定植外,细菌从胃肠道转移到血液中的风险还受到母亲健康、分娩史和婴儿 NICU 病程的影响和修改。虽然冷冻和/或巴氏消毒母乳可以减少或消除其细菌负荷,但也会降低其免疫和营养益处。