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肝结节病:诊断方法与管理

Hepatic Sarcoidosis: Diagnostic approach and management.

作者信息

Hon S A, Lee L T, Tan K K, Lee R A, Low Q J

机构信息

Hospital Sultanah Nora Ismail, Department of Internal Medicine, Batu Pahat, Johor, Malaysia.

Hospital Sultanah Aminah, Department of Surgery, Johor Bahru, Johor, Malaysia.

出版信息

Med J Malaysia. 2021 Nov;76(6):914-917.

Abstract

Sarcoidosis is a multi-systemic, non-caseating granulomatous disorder with an idiopathic aetiology. We report a 58-year-old Malay woman, with underlying type II diabetes mellitus, hypertension and history of stage II pulmonary sarcoidosis presenting with incidental finding of multiple hypodense liver lesions. Her recent contrasted enhanced computed tomography of the abdomen and pelvis demonstrated multiple intra-abdominal lymphadenopathies with evidence of liver and splenic infiltrations. Her ageappropriate malignancy screening was negative while liver biopsy showed non-caseating granulomatous hepatitis consistent with hepatic sarcoidosis. In view of her normal liver enzymes and normalised serum calcium levels, no immunosuppressive therapy was commenced. She remains asymptomatic and is currently under our close monitoring.

摘要

结节病是一种病因不明的多系统非干酪样肉芽肿性疾病。我们报告一名58岁的马来女性,患有II型糖尿病、高血压,有II期肺结节病病史,偶然发现肝脏有多个低密度病变。她最近的腹部和盆腔增强计算机断层扫描显示有多个腹腔内淋巴结肿大,并有肝脏和脾脏浸润的迹象。她的适龄恶性肿瘤筛查结果为阴性,而肝脏活检显示为与肝结节病一致的非干酪样肉芽肿性肝炎。鉴于她的肝酶正常且血清钙水平正常,未开始免疫抑制治疗。她仍无症状,目前正在我们的密切监测之下。

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