热疗对 2 型糖尿病患者有益：系统评价和荟萃分析。

Heat therapy shows benefit in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.

机构信息

2nd Department of Medicine and Nephrology-Diabetes Center, Medical School, University of Pécs, Pécs, Hungary.

Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.

出版信息

Int J Hyperthermia. 2021;38(1):1650-1659. doi: 10.1080/02656736.2021.2003445.

DOI:10.1080/02656736.2021.2003445

PMID:34808071

Abstract

AIMS

Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence increases with age. Besides lifestyle modifications, passive heating could be a promising intervention to improve glycemic control. This study aimed to assess the efficacy of passive heat therapy on glycemic and cardiovascular parameters, and body weight among patients with T2DM.

METHODS

A systematic review and meta-analysis were reported according to PRISMA Statement. We conducted a systematic search in three databases (MEDLINE, Embase, CENTRAL) from inception to 19 August 2021. We included interventional studies reporting on T2DM patients treated with heat therapy. The main outcomes were the changes in pre-and post-treatment cardiometabolic parameters (fasting plasma glucose, glycated plasma hemoglobin, and triglyceride). For these continuous variables, weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Study protocol number: CRD42020221500.

RESULTS

Five studies were included in the qualitative and quantitative synthesis, respectively. The results showed a not significant difference in the hemoglobin A1c [WMD -0.549%, 95% CI (-1.262, 0.164), = 0.131], fasting glucose [WMD -0.290 mmol/l, 95% CI (-0.903, 0.324), = 0.355]. Triglyceride [WMD 0.035 mmol/l, 95% CI (-0.130, 0.200), = 0.677] levels were comparable regarding the pre-, and post intervention values.

CONCLUSION

Passive heating can be beneficial for patients with T2DM since the slight improvement in certain cardiometabolic parameters support that. However, further randomized controlled trials with longer intervention and follow-up periods are needed to confirm the beneficial effect of passive heat therapy.

摘要

目的

2 型糖尿病（T2DM）是一种常见的健康状况，其患病率随着年龄的增长而增加。除了生活方式的改变，被动加热可能是改善血糖控制的一种有前途的干预措施。本研究旨在评估被动热疗对 T2DM 患者血糖和心血管参数以及体重的疗效。

方法

根据 PRISMA 声明报告了系统评价和荟萃分析。我们在三个数据库（MEDLINE、Embase、CENTRAL）中进行了系统检索，检索时间从建库至 2021 年 8 月 19 日。我们纳入了报告 T2DM 患者接受热疗治疗的干预性研究。主要结局是治疗前后代谢参数（空腹血糖、糖化血浆血红蛋白和甘油三酯）的变化。对于这些连续变量，计算了加权均数差值（WMD）及其 95%置信区间（CI）。研究方案编号：CRD42020221500。

结果

五项研究分别进行了定性和定量综合分析。结果显示，血红蛋白 A1c 差异无统计学意义[WMD -0.549%，95%CI（-1.262，0.164），=0.131]，空腹血糖[WMD -0.290mmol/l，95%CI（-0.903，0.324），=0.355]。治疗前后甘油三酯[WMD 0.035mmol/l，95%CI（-0.130，0.200），=0.677]水平相当。