Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Ophthalmology, Meir Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Kfar Saba, Israel.
Ophthalmologica. 2022;245(4):342-349. doi: 10.1159/000520930. Epub 2021 Nov 22.
The aim of the study was to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularization (PPCNV).
The study involved a retrospective case series of consecutive patients diagnosed with PPCNV secondary to AMD. All patients were treated with IVB injections with a follow-up time of 1 year. Data collected included best-corrected visual acuity (BCVA) and automated and manually measured OCT parameters.
A total of 68 eyes were diagnosed with PPMV. Of them, 30 eyes of 30 patients aged 84.3 ± 6.9 years of which 63.3% female gender were included. Baseline BCVA was 0.46 ± 0.62 logMAR (Snellen 20/57), average choroidal thickness was 193.2 ± 22 μm, and mean number of IVB injections was 7.2 ± 1.9. After 1 year, BCVA was 0.56 ± 0.78 logMAR (Snellen 20/72) (p = 0.28). Eyes with greater central retinal thickness (r = -0.36, p = 0.05), greater subretinal hyper-reflective material (SHRM) area (r = -0.37, p = 0.05), and greater sub-retinal fluid (SRF) area (r = -0.73, p < 0.001) had a significantly smaller improvement in BCVA. Eyes with pigment epithelium detachment (PED) (0.68 ± 0.90 vs. 0.21 ± 0.12, p = 0.03) had a significantly worse BCVA.
Our data suggest that AMD-related PPCNV with greater foveal thickness, PED size, SHRM, and SRF areas have worse final BCVA prognosis.
本研究旨在探讨伴有旁中心脉络膜新生血管（PPCNV）的年龄相关性黄斑变性（AMD）患者接受玻璃体内贝伐单抗（IVB）注射治疗后，光学相干断层扫描（OCT）结果与视力结局的相关性。
本研究为回顾性病例系列研究，纳入了继发于 AMD 的 PPCNV 连续患者。所有患者均接受 IVB 注射治疗，随访时间为 1 年。收集的数据包括最佳矫正视力（BCVA）和自动及手动测量的 OCT 参数。
共诊断出 68 只眼患有 PPCNV。其中，30 只眼（30 例患者）的年龄为 84.3 ± 6.9 岁，其中 63.3%为女性。基线时 BCVA 为 0.46 ± 0.62 logMAR（Snellen 20/57），平均脉络膜厚度为 193.2 ± 22 μm，平均 IVB 注射次数为 7.2 ± 1.9。1 年后，BCVA 为 0.56 ± 0.78 logMAR（Snellen 20/72）（p = 0.28）。中央视网膜厚度更大（r = -0.36，p = 0.05）、视网膜下强反射物质（SHRM）面积更大（r = -0.37，p = 0.05）和视网膜下液（SRF）面积更大（r = -0.73，p < 0.001）的眼，BCVA 改善显著较小。有色素上皮脱离（PED）的眼（0.68 ± 0.90 与 0.21 ± 0.12，p = 0.03）的 BCVA 显著更差。
我们的数据表明，AMD 相关的 PPCNV 中，中央凹厚度更大、PED 大小更大、SHRM 和 SRF 面积更大的患者，最终 BCVA 预后更差。
