Zhang Lei, Luo Yuanxiang
Department of ophthalmology, The First Affiliated Hospital of Shihezi University, Xinjiang Uygur Autonomous Region, No.107 BeiNorth Road, Shihezi City, 832000, China.
Department of ophthalmology, Chengdu Fifth People's Hospital, Sichuan, 61000, China.
BMC Ophthalmol. 2025 May 6;25(1):266. doi: 10.1186/s12886-025-04094-9.
To explore the correlation between optical coherence tomography (OCT) evaluations and postoperative visual prognosis in individuals with AMD complicated with cataract, and to investigate the clinical applications of these evaluations for predicting visual outcomes.
We retrospectively analyzed the clinical data of 132 individuals (132 eyes) with AMD complicated by cataract, admitted to our hospital from April 2022 to January 2024. All patients underwent surgical treatment and were categorized into two groups based on their visual prognosis after 6 months: the "good prognosis (GP)" group (best corrected visual acuity decrease < 0.1 logMAR) and the "poor prognosis (PP)" group (best corrected visual acuity decrease ≥ 0.1 logMAR). We evaluated OCT parameters including central retinal thickness (CRT), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and total average macular thickness (TR). Pearson correlation analysis was employed to assess the relationship between these OCT parameters and postoperative visual outcomes. Additionally, receiver operating characteristic (ROC) were used to calculate the predictive value of OCT measurements for identifying poor postoperative visual prognosis in this patient cohort.
Preoperative OCT results showed significantly higher values for CMT, CRT, TR, and SFCT in the PP group compared to the GP group (P < 0.05). Pearson correlation analysis revealed a positive association between postoperative visual acuity and these OCT parameters. Logistic regression modeling identified CMT, CRT, TR, and SFCT as key predictors of poor visual prognosis in AMD patients with cataract. ROC analysis showed that combining these parameters improved the prediction accuracy, with an area under the curve (AUC) of 0.993, sensitivity of 99.87%, and specificity of 95.30%, which were significantly higher compared to single-index evaluations (P < 0.05).
CMT, CRT, TR, SFCT are obviously related to the postoperative visual prognosis in patients with AMD complicated by cataract. The combined evaluation of these OCT parameters demonstrates high predictive efficiency for poor postoperative visual prognosis and can serve as an important assessment index for evaluating the postoperative visual prognosis in this patient population.
探讨年龄相关性黄斑变性（AMD）合并白内障患者的光学相干断层扫描（OCT）评估与术后视力预后之间的相关性，并研究这些评估对预测视力结果的临床应用。
我们回顾性分析了2022年4月至2024年1月期间我院收治的132例（132只眼）AMD合并白内障患者的临床资料。所有患者均接受手术治疗，并根据6个月后的视力预后分为两组：“预后良好（GP）”组（最佳矫正视力下降<0.1 logMAR）和“预后不良（PP）”组（最佳矫正视力下降≥0.1 logMAR）。我们评估了OCT参数，包括视网膜中央厚度（CRT）、黄斑中心厚度（CMT）、黄斑下脉络膜厚度（SFCT）和总平均黄斑厚度（TR）。采用Pearson相关性分析评估这些OCT参数与术后视力结果之间的关系。此外，使用受试者工作特征（ROC）曲线来计算OCT测量对该患者队列中术后视力预后不良的预测价值。
术前OCT结果显示，PP组的CMT、CRT、TR和SFCT值显著高于GP组（P<0.05）。Pearson相关性分析显示术后视力与这些OCT参数呈正相关。Logistic回归模型确定CMT、CRT、TR和SFCT是AMD合并白内障患者视力预后不良的关键预测因素。ROC分析表明，综合这些参数可提高预测准确性，曲线下面积（AUC）为0.993，敏感性为99.87%，特异性为95.30%，与单指标评估相比显著更高（P<0.05）。
CMT、CRT,、TR、SFCT与AMD合并白内障患者的术后视力预后明显相关。这些OCT参数的联合评估对术后视力预后不良具有较高的预测效率，可作为评估该患者群体术后视力预后的重要评估指标。
