Antibiot Chemother (1971). 1978;23:99-112.
Cis-diamminedichloroplatinum (DDP) leads the series of platinum coordination complexes and shows definite and striking efficacy against germinal tumors of the testis. Results are also promising in epithelial malignancies including carcinoma of the ovary, bladder, prostate, cervix, and carcinomas of head and neck origin. Toxicities include nephrotoxicity, ototoxicity, and mild to moderate myelosuppression; severe nausea and vomiting have occurred in all schedules tested. After several years of limited clinical investigation, interest in DDP has been renewed by: (a) recent discovery that induced diuresis circumvents the nephrotoxicity seen in earlier trials; (b) subsequent definition of safer larger doses than previous ones; (c) better understanding of pharmacology, and (d) the expectation of synergistic effects with several other anticancer agents. Extensive future use of DDP may be predicted in the treatment of cancer patients although its clinical potential remains to be investigated in a number of tumor types. Major ongoing efforts also include studies on the mechanism of action and pharmacologic properties of DDP, and development of other platinum compounds with improved therapeutic indices.
顺二氯二氨铂（DDP）是铂配位络合物系列中的一种，对睾丸生殖细胞瘤显示出确切且显著的疗效。在包括卵巢癌、膀胱癌、前列腺癌、宫颈癌以及头颈部癌在内的上皮性恶性肿瘤中，治疗结果也很有前景。毒性包括肾毒性、耳毒性以及轻度至中度骨髓抑制；在所有测试方案中均出现过严重的恶心和呕吐。经过数年有限的临床研究，对DDP的兴趣得以重新燃起，原因如下：（a）最近发现诱导利尿可避免早期试验中出现的肾毒性；（b）随后确定了比以前更安全的大剂量；（c）对药理学有了更好的理解；（d）期望与其他几种抗癌药物产生协同作用。尽管DDP的临床潜力在多种肿瘤类型中仍有待研究，但可以预测其在癌症患者治疗中的广泛应用前景。正在进行的主要工作还包括对DDP作用机制和药理学特性的研究，以及开发具有更好治疗指数的其他铂化合物。
