Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-mimamimachi, Chuo-ku, Kobe 650-0047, Japan.
Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-mimamimachi, Chuo-ku, Kobe 650-0047, Japan.
Chem Commun (Camb). 2021 Dec 21;58(1):48-51. doi: 10.1039/d1cc05523b.
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significantly affected transcription efficiency. These results suggest an impact of neighboring sequences on the gene expression of guanine-rich sequences.
我们在蛋白酶基因中鉴定到了临近鸟嘌呤富集区的胞嘧啶富集区。来源于 基因的典型 GC 富集序列表现出 G-四链体和发夹环之间的结构竞争，这种竞争显著影响了转录效率。这些结果表明了临近序列对富含鸟嘌呤序列的基因表达的影响。
