Hermanussen M, Geiger-Benoit K, Burmeister J, Sippell W G
Department of Paediatrics, Children's Hospital, West Germany.
Acta Paediatr Scand Suppl. 1987;337:30-6. doi: 10.1111/j.1651-2227.1987.tb17124.x.
A total of 105 healthy children of both sexes and various ages were measured once or twice weekly by knemometry over periods of 161-202 days on 11-50 occasions. These data were used to calculate percentiles of the predictive error that occurred if short-term lower leg length differences were used to extrapolate half-annual growth rates. From these data, and observations on day-to-day variations of the lower leg length, it was concluded that growth rates derived from single differences between two consecutive lower leg length measurements are invalid and without predictive power for mean long-term lower leg increments. However, a novel statistical approach is presented, which results in the evaluation of daily lower leg growth rates to visualize quasi-continuous growth kinetics. Examples of successful and unsuccessful growth promoting therapeutic interventions are provided to demonstrate knemometric assessment of a significant modification of short-term growth kinetics.
共有105名不同年龄和性别的健康儿童，在161至202天的时间里，每周测量1至2次小腿长度，测量次数为11至50次。这些数据用于计算如果用短期小腿长度差异推断半年生长速率时出现的预测误差百分位数。根据这些数据以及对小腿长度每日变化的观察结果得出结论：由连续两次小腿长度测量的单一差异得出的生长速率是无效的，对小腿的长期平均增长没有预测能力。然而，本文提出了一种新颖的统计方法，该方法可用于评估每日小腿生长速率，以直观呈现近似连续的生长动力学。文中提供了成功和不成功的促进生长治疗干预的实例，以证明通过小腿长度测量法评估短期生长动力学的显著变化。
