Wit J M, van Kalsbeek E J, van Wijk-Hoek J M, Leppink G J
Department of Paediatrics, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Ultrecht, The Netherlands.
Acta Paediatr Scand. 1987 Nov;76(6):974-80. doi: 10.1111/j.1651-2227.1987.tb17274.x.
In 31 healthy children the variability of lower leg length growth over 12 weekly measuring sessions, each consisting of 6 measurements, was assessed with a knemometer. The average SD of 6 measurements was 0.12 mm. In many cases not only a rising trend, but also a zig-zag pattern was observed. The linear regression was not significant (p greater than 0.05) in 1 child. The average (+/- SD) lower leg length velocity (LV) was 0.36 +/- 0.14 mm/week, and the average statural growth velocity 1.27 +/- 0.54 mm/week. The median ratio was 3.3. The range of both velocities was greater than the range of annual height velocities. When LV over the first 6 weeks was compared with LV over the next 6 weeks, a significant difference was found in 5 children. If the effect of growth-promoting or -inhibiting drugs were to be analyzed over such periods, a difference of 0.37 mm/week over two 6-week-periods would be necessary for significance at a 5% level. This would be equivalent with a statural growth response of at least 6.3 cm/year. In conclusion, short-term knemometric growth response cannot be used as a reliable predictor of long-term statural growth response.
在31名健康儿童中，使用小腿长度测量仪评估了在12次每周测量过程中（每次测量包含6次测量）小腿长度增长的变异性。6次测量的平均标准差为0.12毫米。在许多情况下，不仅观察到增长趋势，还观察到锯齿状模式。在1名儿童中，线性回归不显著（p大于0.05）。小腿长度平均（±标准差）增长速度（LV）为0.36±0.14毫米/周，平均身高增长速度为1.27±0.54毫米/周。中位数比率为3.3。两种速度的范围均大于年身高速度范围。当比较前6周的LV与后6周的LV时，在5名儿童中发现了显著差异。如果要分析在这样的时间段内促进生长或抑制生长药物的效果，在两个6周时间段内每周相差0.37毫米才具有5%水平的显著性。这相当于身高增长反应至少为6.3厘米/年。总之，短期小腿长度测量生长反应不能用作长期身高生长反应的可靠预测指标。
