Ding Chenchen, Wu Huixian, Cao Xiuyun, Ma Xujie, Gao Xiaona, Gao Zhangshan, Liu Shuhui, Fan Wentao, Liu Bin, Song Suquan
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Management office of Dafeng Milu National Nature Reserve, Yancheng, 224136, China.
Food Funct. 2021 Dec 13;12(24):12535-12549. doi: 10.1039/d1fo03209g.
Long-term use of antibiotic growth promoter (AGP) in animal production is the main cause of antimicrobial resistance of pathogenic bacteria. Therefore, seeking alternatives to AGP is crucial for animal husbandry. Among all AGP alternatives, probiotics are promising candidates. In this study, two strains of lactic acid bacteria, and , were isolated from the feces of wild , which exhibited obvious anti-pathogenic activity and improved the growth performance of broilers. Furthermore, we found that these two strains participated in the lipid metabolism of broilers by reducing the content of TC and TG in ileal epithelial cells and up-regulating the liver AMPKα/PPARα/CPT-1 pathway, which affects abdominal fat deposition. In summary, and have the potential to be used as AGP substitutes and participate in the lipid metabolism of broilers to reduce abdominal fat deposition. Importantly, our study reveals for the first time that participates in liver lipid metabolism to reduce abdominal fat deposition in broilers.
在动物生产中长期使用抗生素生长促进剂（AGP）是病原菌产生抗微生物耐药性的主要原因。因此，寻找AGP的替代品对畜牧业至关重要。在所有AGP替代品中，益生菌是很有前景的候选者。在本研究中，从野生[某种动物]的粪便中分离出两株乳酸菌，[菌株名称1]和[菌株名称2]，它们表现出明显的抗病原菌活性并改善了肉鸡的生长性能。此外，我们发现这两株菌通过降低回肠上皮细胞中总胆固醇（TC）和甘油三酯（TG）的含量以及上调肝脏中的腺苷酸活化蛋白激酶α（AMPKα）/过氧化物酶体增殖物激活受体α（PPARα）/肉碱棕榈酰转移酶1（CPT-1）途径参与肉鸡的脂质代谢，该途径影响腹部脂肪沉积。总之，[菌株名称1]和[菌株名称2]有潜力用作AGP替代品并参与肉鸡的脂质代谢以减少腹部脂肪沉积。重要的是，我们的研究首次揭示[菌株名称1]参与肝脏脂质代谢以减少肉鸡腹部脂肪沉积。
