Key Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, PR China.
School of Life Sciences, Lanzhou University, Lanzhou, PR China.
Anim Biotechnol. 2023 Nov;34(4):819-824. doi: 10.1080/10495398.2021.1998091. Epub 2021 Nov 23.
The () gene family, including , and , codes transcriptional repressors which could accurately control biological rhythms. gene was proved to be associated with bone mass and gene was associated with insulin-like growth factor binding proteins 3 (IGFBP3) levels in serum. However, it was few studies reported genetic effects of gene on growth traits at the individual level. In this study, we identified the potential insertion/deletion (indel) loci in gene, and then explored the relationship between goat growth traits and the frequency of genotype in Shaanbei white cashmere goats ( = 827). As a result, a 9 bp indel within gene (g.27528003-27528011 del.TGCTGCTGC; rs642467689) was identified using molecular biology techniques. In addition, there existed significant correlation between the 9 bp indel and body height, height at hip cross, chest depth, body length index and cannon circumference index of goats. These results suggested that the 9 bp indel variation in gene was associated with goat growth traits, providing the theoretical basic for the role of gene in goat breeding.
（）基因家族，包括、和，编码转录阻遏物，可以精确地控制生物节律。基因被证明与骨量有关，基因与血清中的胰岛素样生长因子结合蛋白 3（IGFBP3）水平有关。然而，很少有研究报道基因对个体水平生长性状的遗传影响。在这项研究中，我们鉴定了基因中的潜在插入/缺失（indel）位点，然后探讨了山羊生长性状与陕西白绒山羊基因型频率之间的关系（n=827）。结果发现，基因内存在一个 9bp 的 indel（g.27528003-27528011del.TGCTGCTGC；rs642467689）。此外，该 9bpindel 与山羊的体高、十字部高、胸深、体长指数和管围指数存在显著相关性。这些结果表明，基因中的 9bpindel 变异与山羊的生长性状有关，为基因在山羊育种中的作用提供了理论基础。
