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[小儿抗磷脂抗体综合征:一例报告]

[The antiphospholipid antibody syndrome in pediatrics: a case report].

作者信息

Fernández Miranda, Tasso Paula, Tedeschini Ignacio, Lómez Julia, López María V, Cheistwer Ariel

机构信息

Unidad 6, Clínica Pediátrica, Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Arch Argent Pediatr. 2021 Dec;119(6):e631-e635. doi: 10.5546/aap.2021.e631.

Abstract

Antiphospholipid syndrome (APS) is infrequent at pediatric age (3 %) and is characterized by venous or arterial thrombosis and/or spontaneous abortions. APS occurs either as a primary condition or in the setting of an underlying disease. This is a case of a 12-year-old girl with a right hemiparesis and acute disturbance in gait, in which an ischemic cerebrovascular accident (CVA) due to middle cerebral artery thrombosis associated with positive antiphospholipid antibodies is confirmed (anticardiolipin antibody, lupus anticoagulant and anti-β2-glycoprotein antibody), fulfilling the criteria for the diagnosis of antiphospholipid syndrome. After starting treatment accordingly, the patient evolves favorably. As this pathology is infrequent and of variable presentation, it requires a high sense of alert from the health team to avoid delays in diagnosis and treatment.

摘要

抗磷脂综合征(APS)在儿童期较为罕见(3%),其特征为静脉或动脉血栓形成和/或自然流产。APS可作为原发性疾病出现,也可在潜在疾病背景下发生。这是一例12岁女孩,出现右侧偏瘫和步态急性障碍,经证实为大脑中动脉血栓形成导致的缺血性脑血管意外(CVA),同时抗磷脂抗体呈阳性(抗心磷脂抗体、狼疮抗凝物和抗β2糖蛋白抗体),符合抗磷脂综合征的诊断标准。相应开始治疗后,患者病情好转。由于这种疾病罕见且表现多样,需要医疗团队保持高度警惕,以避免诊断和治疗延误。

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