Professor and Pediatric Cardiologist, College of Medicine, Department of pediatrics, University of Nigeria/University of Nigeria Teaching Hospital (UNTH), Ituku- Ozalla, Enugu State, Nigeria.
Senior Lecturer, Department of Paediatrics and Child health, Niger Delta University Teaching Hospital, Nigeria.
Libyan J Med. 2022 Dec;17(1):2007603. doi: 10.1080/19932820.2021.2007603.
Atrial septal defect (ASD) is a common congenital heart disease in children that uncommonly presents with pulmonary hypertension. Much is not known about the exact predictor of PAH in children with ASD.
This study aimed to determine the predictors of pulmonary hypertension in children with ASD.
This was a descriptive analysis of children with ASD carried out in three different institutions over a five-year period. Data entry and analysis were done using IBM Statistical Package for Social Sciences (SPSS) statistical software, version 25.
The majority of the participants, 52.2%, had pulmonary hypertension and 62.5% of them occurred as mild pulmonary hypertension. There was a very weak positive correlation between pulmonary hypertension and the size of atrial septal defect, increases in size of atrial septal defect correlate with increases in pulmonary hypertension and this was found not to be statistically significant (n = 67, r = 0.193, p = 0.118). There was a positive correlation between the size of atrial septal defect and the age of participants in months, increases in age correlate with increases in size of atrial septal defect and this was found to be statistically significant (n = 67, r = 0.357, p = 0.003).The highest proportion of respondents who had pulmonary hypertension, 64.7%, was seen among children less than 1 year old while the least proportion, 27.3%, was within 1-5 years, and the difference in proportions was found to be statistically significant (χ = 8.187, p = 0.017).
Pulmonary hypertension in children with ASD occur usually in the mild form. Age is the only strong predictor of PAH in children with isolated ASD.
房间隔缺损（ASD）是儿童常见的先天性心脏病，不常见于肺动脉高压。关于 ASD 患儿肺动脉高压的确切预测因素知之甚少。
本研究旨在确定 ASD 患儿肺动脉高压的预测因素。
这是一项在五年内在三个不同机构进行的 ASD 患儿描述性分析。数据录入和分析使用 IBM 统计软件包（SPSS）统计软件，版本 25。
大多数参与者（52.2%）患有肺动脉高压，其中 62.5%为轻度肺动脉高压。肺动脉高压与房间隔缺损大小之间存在非常弱的正相关，房间隔缺损大小的增加与肺动脉高压的增加相关，但无统计学意义（n=67，r=0.193，p=0.118）。房间隔缺损大小与参与者年龄呈正相关，年龄的增加与房间隔缺损大小的增加相关，这具有统计学意义（n=67，r=0.357，p=0.003）。肺动脉高压比例最高的是年龄小于 1 岁的儿童，占 64.7%，而比例最低的是 1-5 岁的儿童，占 27.3%，差异具有统计学意义（χ=8.187，p=0.017）。
ASD 患儿的肺动脉高压通常呈轻度。年龄是 ASD 患儿唯一的肺动脉高压强预测因素。
