The Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia.
Drug Alcohol Depend. 2021 Dec 1;229(Pt B):109184. doi: 10.1016/j.drugalcdep.2021.109184. Epub 2021 Nov 17.
Alcohol Use Disorder (AUD) is a significant contributor to global disease burden. AUD has a relatively early onset during young adulthood (Teesson et al., 2010). However, compared to AUD in adults, we have relatively little understanding of AUD in adolescents and emerging adults.
The RADAR study is a prospective cohort study designed to investigate the emergence of AUD in community-dwelling adolescents and emerging adults across Australia (age range = 18-21 at baseline). At 6 monthly intervals over 2.5 years, participants were interviewed regarding alcohol consumption and alcohol use disorder criteria by clinical psychologists using the SCID-IV-RV. This paper reports the baseline findings of the RADAR cohort.
Proportions of lifetime criteria endorsement among regular drinkers varied considerably. Tolerance was the most endorsed criterion (50.3%), followed by Social Problems (10.4%) and Larger/Longer (9.0%). The median age of onset for most individual AUD criteria was 18 years of age. 18.4% of our cohort met DSM-5 AUD diagnosis in their lifetime to date, and 16.8% met ICD-11 dependence. When removing Tolerance from the AUD criteria, DSM-5 AUD lifetime prevalence reduced to 11.0%, and ICD-11 AUD lifetime prevalence fell to 7.1% in our cohort.
Variable rates of criteria endorsement likely reflect both true differences in the experience of AUD criteria and methodological challenges in the assessment of AUD in an emerging adult age group. High rates of tolerance to the effects of alcohol, and relatively low rates of drinking larger/longer than intended are discussed considering methodological challenges in assessing these criteria in young adults.
酒精使用障碍（AUD）是全球疾病负担的重要因素。 AUD 在年轻人中发病较早（Teesson 等人，2010 年）。然而，与成人 AUD 相比，我们对青少年和刚成年人群体中的 AUD 了解相对较少。
RADAR 研究是一项前瞻性队列研究，旨在调查澳大利亚社区青少年和刚成年人群中 AUD 的发生情况（基线年龄为 18-21 岁）。在 2.5 年的时间里，每隔 6 个月，临床心理学家使用 SCID-IV-RV 对参与者进行酒精消费和酒精使用障碍标准的访谈。本文报告了 RADAR 队列的基线研究结果。
在经常饮酒者中，终生标准的比例差异很大。耐受性是最受认可的标准（50.3%），其次是社会问题（10.4%）和更大/更长（9.0%）。大多数 AUD 标准的发病中位年龄为 18 岁。迄今为止，我们队列中 18.4%的人符合 DSM-5 AUD 诊断，16.8%的人符合 ICD-11 依赖性。当从 AUD 标准中去除耐受性时，DSM-5 AUD 的终生患病率降低至 11.0%，而我们队列中的 ICD-11 AUD 终生患病率降至 7.1%。
标准认可率的差异可能反映了 AUD 标准在体验上的真实差异，以及在评估刚成年人群体中的 AUD 时的方法学挑战。考虑到在年轻人中评估这些标准的方法学挑战，高比例的对酒精影响的耐受性和相对较低的比预期更大/更长的饮酒量的比例被讨论。
