Dresden Courtney E, Ashraf Quratulayn, Husbands Aman Y
Molecular, Cellular, and Developmental Biology (MCDB), the Ohio State University, Columbus, OH 43215, USA.
Molecular, Cellular, and Developmental Biology (MCDB), the Ohio State University, Columbus, OH 43215, USA; Department of Molecular Genetics, The Ohio State University, Columbus, OH 43215, USA; Center for Applied Plant Sciences (CAPS), The Ohio State University, Columbus, OH 43215, USA.
Curr Opin Plant Biol. 2021 Dec;64:102148. doi: 10.1016/j.pbi.2021.102148. Epub 2021 Nov 20.
The StARkin domain (derived from 'kin of steroidogenic acute regulatory protein (StAR)') is an evolutionarily conserved helix-grip-fold structure. StARkin domains possess a deep hydrophobic pocket capable of binding lipophilic ligands such as fatty acids, sterols, and isoprenoids. Dysregulation of StARkin proteins has profound effects on disease and development. In this review, we profile recent mechanistic and evolutionary studies, which highlight the remarkable diversity of regulatory mechanisms employed by the StARkin module. Although primarily focused on land plants, we also discuss select key advances in mammalian StARkin biology. The diversity of perspectives, systems, and approaches described here may be helpful to researchers characterizing poorly understood StARkin proteins.
类固醇生成急性调节蛋白相关结构域（源自“类固醇生成急性调节蛋白（StAR）的亲属”）是一种进化上保守的螺旋握褶结构。类固醇生成急性调节蛋白相关结构域拥有一个深疏水口袋，能够结合亲脂性配体，如脂肪酸、固醇和类异戊二烯。类固醇生成急性调节蛋白相关蛋白的失调对疾病和发育有深远影响。在本综述中，我们概述了最近的机制和进化研究，这些研究突出了类固醇生成急性调节蛋白相关模块所采用的调节机制的显著多样性。虽然主要关注陆地植物，但我们也讨论了哺乳动物类固醇生成急性调节蛋白相关生物学的一些关键进展。这里描述的观点、系统和方法的多样性可能有助于研究人员鉴定了解不足的类固醇生成急性调节蛋白相关蛋白。
