Clinic of Vascular Medicine, HELIOS Klinik Krefeld, Krefeld, Germany.
Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia.
Hamostaseologie. 2022 Jun;42(3):174-179. doi: 10.1055/a-1528-0513. Epub 2021 Nov 23.
This article aimed to compare nationwide time trends of oral anticoagulant prescriptions with the time trend of hospitalization for tooth extraction (TE) in Germany from 2006 through 2017.
We derived the annual number of hospital admissions for TE from the Nationwide Hospital Referral File of the Federal Bureau of Statistics and defined daily doses (DDD) of prescribed anticoagulants in outpatients from reports of the drug information system of the statutory health insurance.
From 2005 to 2017, annual oral anticoagulation (OAC) treatment rates increased by 143.7%. In 2017, direct oral anticoagulants (DOACs) represented 57.1% of all OAC treatments. The number of cases hospitalized for TE increased by 28.0 only. From all the cases hospitalized for TE in Germany in 2006, 14.2% had a documented This proportion increased to 19.6% in 2017. Age-standardized hospitalization rates for all TE cases with increased from 6.6 in 2006 to 10.5 cases per 100,000 person-years in 2014 and remained almost unchanged thereafter.
Our comparison showed that the large increase in OAC treatment rates in general from 2006 to 2017 had only a small impact on hospitalized TE cases with long-term use of OAC which flattens since 2014.
本文旨在比较 2006 年至 2017 年德国全国范围内口服抗凝剂处方的时间趋势与拔牙（TE）住院的时间趋势。
我们从联邦统计局的全国医院转诊档案中得出每年 TE 住院人数，并从法定健康保险药物信息系统的报告中定义了门诊患者规定抗凝剂的日剂量（DDD）。
从 2005 年到 2017 年，每年口服抗凝（OAC）治疗率增加了 143.7%。2017 年，直接口服抗凝剂（DOAC）占所有 OAC 治疗的 57.1%。TE 住院人数仅增加了 28.0。在德国，2006 年所有因 TE 住院的病例中，有 14.2%有记录表明该病例长期使用 OAC。这一比例在 2017 年上升到 19.6%。所有 TE 病例的年龄标准化住院率从 2006 年的 6.6 例增加到 2014 年的每 10 万人 10.5 例，此后基本保持不变。
我们的比较表明，2006 年至 2017 年 OAC 治疗率的大幅增长对长期使用 OAC 的 TE 住院病例的影响较小，自 2014 年以来基本保持不变。
