Xu J H, Yu Y Y, Xu X Y
Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
Zhonghua Gan Zang Bing Za Zhi. 2021 Oct 20;29(10):915-918. doi: 10.3760/cma.j.cn501113-20210902-00445.
Epstein-Barr virus (EBV) infection is closely associated to liver injury with diverse clinical features in adolescents and adults. It is often manifested as infectious mononucleosis syndrome, sometimes causing self-limited acute hepatitis, with mild to moderate elevation of liver transaminases, and relative increase in age-related conditions. EBV infection can also cause cholestatic hepatitis, with elevated alkaline phosphatase and γ-glutamyltransferase as the main manifestations, accompanied by varying degrees of jaundice. A small number of patients with severe EBV infection may experience liver failure, and if left untreated in time, it may lead to high mortality. In addition, EBV infection is also associated with chronic hepatitis, liver cirrhosis, autoimmune liver disease, etc.
爱泼斯坦-巴尔病毒（EBV）感染与青少年及成人肝脏损伤密切相关，具有多样的临床特征。其常表现为传染性单核细胞增多综合征，有时可引发自限性急性肝炎，伴有肝转氨酶轻度至中度升高，且与年龄相关的病症相对增多。EBV感染还可导致胆汁淤积性肝炎，主要表现为碱性磷酸酶和γ-谷氨酰转移酶升高，伴有不同程度的黄疸。少数严重EBV感染患者可能会出现肝衰竭，若未及时治疗，可能导致高死亡率。此外，EBV感染还与慢性肝炎、肝硬化、自身免疫性肝病等有关。
