柠檬酸钠对67Ga血液清除的影响。

Effect of sodium citrate on the blood disappearance of 67Ga.

作者信息

Kohno H, Ohkubo Y, Kubodera A

机构信息

Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai-shi, Japan.

出版信息

Radioisotopes. 1987 Oct;36(10):523-5. doi: 10.3769/radioisotopes.36.10_523.

DOI:10.3769/radioisotopes.36.10_523

PMID:3481443

Abstract

The effect of sodium citrate on the blood disappearance of 67Ga was examined in rats. The half life value of the alpha phase and the initial AUC value (0-60 min) were dose-dependently decreased by sodium citrate. The binding of 67Ga to serum proteins was also dose-dependently inhibited by sodium citrate.

摘要

在大鼠中研究了柠檬酸钠对67Ga血液清除率的影响。柠檬酸钠使α相的半衰期值和初始AUC值（0 - 60分钟）呈剂量依赖性降低。柠檬酸钠还对67Ga与血清蛋白的结合产生剂量依赖性抑制作用。